PMID: 9423824Jan 10, 1998Paper

Successful treatment of severe refractory idiopathic thrombocytopenic purpura with liposomal doxorubicin

American Journal of Hematology
T M CosgriffW Stein

Abstract

Idiopathic thrombocytopenic purpura (ITP) is refractory to initial treatment (steroids and splenectomy) in 25 to 30% of patients. These patients have a significant risk of fatal hemorrhage. Two patients with ITP refractory to multiple interventions and severe depression of platelet counts responded to treatment with liposomal doxorubicin with a return of platelet counts to normal. The drug is easily administered and was well tolerated. Use of this drug in refractory ITP merits further study.

References

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Nov 3, 1994·The New England Journal of Medicine·J N GeorgeG E Raskob
Feb 15, 1997·Annals of Internal Medicine·R McMillan
Feb 15, 1997·Annals of Internal Medicine·J N George, F Davidoff

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Citations

Feb 18, 2003·British Journal of Haematology·UNKNOWN British Committee for Standards in Haematology General Haematology Task Force
Jun 13, 2001·Pharmacotherapy·A L Goram, P L Richmond
Oct 16, 2007·Current Opinion in Hematology·Bertrand GodeauJames Bussel
Dec 2, 2004·Expert Opinion on Pharmacotherapy·S Gerald Sandler, S Osman Tutuncuoglu
Apr 7, 2004·Mayo Clinic Proceedings·Roberto Stasi, Drew Provan

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