PMID: 2501237Jun 1, 1989Paper

Successful treatment of superior vena cava syndrome with urokinase in an infant with a central venous catheter

Helvetica paediatrica acta
M K Caglar, J Tolboom

Abstract

An infant with superior vena cava syndrome due to thrombus formation in the superior vena cava, sourced from a central venous line, was treated with urokinase. It was used in a loading dose of 250,000 units/1.73 m2/15 min, followed by continuous infusion of 125,000 units/1.73 m2/h for three days. After two days of urokinase treatment, the clinical signs of superior vena cava syndrome completely disappeared. No bleeding complication was observed.

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