Oct 16, 2013

Successful treatment with a combination of electrocautery using wire snares and gefitinib in patients with EGFR-mutant lung cancer and central airway obstruction

Internal Medicine
Tomoyuki ArayaKoichi Nishi


One-third of lung cancer patients present with life-threatening central airway obstruction (CAO). Two elderly patients were referred to our institution with symptoms caused by CAO. In each case, thoracic computed tomography and a bronchoscopic examination revealed a tumor obstructing the central airway. The tumors were resected endoscopically, and the patients' respiratory and performance status remarkably improved. Both patients were diagnosed with an advanced stage of lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutations. They received gefitinib monotherapy, with partial responses sustained for more than 12 months. Combination therapy with endoscopic tumor resection and gefitinib is beneficial in patients with EGFR-mutant lung cancer and CAO.

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Mentioned in this Paper

Endoscopy (Procedure)
Adenocarcinoma of Lung (Disorder)
Antineoplastic Agents
Epidermal Growth Factor Receptor Activity
X-Ray Computed Tomography
Dissecting Aneurysm of the Thoracic Aorta
Carcinoma of Lung

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