Successful treatment with allogeneic peripheral blood stem cell transplantation and granulocyte transfusion for severe aplastic anemia with sinusitis

Transplant Infectious Disease : an Official Journal of the Transplantation Society
M TakahataI Maekawa

Abstract

A 43-year-old woman with severe aplastic anemia (SAA) received anti-thymocyte globulin and cyclosporin A (CyA) and achieved hematological remission. Although she had maintained hematological remission, the disease relapsed 10 months after arbitrary discontinuance of maintenance therapy with CyA. Resumption of CyA therapy was not effective, and her condition became complicated with progressive sinusitis with bone destruction, which was refractory to antibiotics, antifungal agents, granulocyte colony-stimulating factor, and surgical drainage. Because of the necessity for early neutrophil recovery (to resolve the infection), we proceeded with a combination therapy using allogeneic peripheral blood stem cell transplantation (PBSCT) promptly followed by granulocyte transfusion (GTX) from the same human leukocyte antigen-identical donor rather than carrying out a second immunosuppressive therapy. The patient showed temporal resolution of infection on the second day after a single GTX. Although the patient had pneumonia on day 11, it was resolved promptly after engraftment on day 16. This report suggests the clinical utility of a salvage therapy with allogeneic PBSCT followed by GTX in a particular case of recurrent SAA with refractor...Continue Reading

References

Jun 1, 1996·Infectious Disease Clinics of North America·S J Chanock, J B Gorlin
Dec 12, 2001·British Journal of Haematology·J ScopesF M Gibson
Nov 25, 2003·British Journal of Haematology·J C W MarshUNKNOWN British Committee for Standards in Haematology
Nov 30, 2004·British Journal of Haematology·M Bishton, R Chopra
Jul 22, 2005·The Cochrane Database of Systematic Reviews·S J StanworthD I Marks
Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN Stem Cell Trialists' Collaborative Group

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Citations

Apr 28, 2005·Clinical Journal of Oncology Nursing·Christine Wilson, Terry Sylvanus
Oct 14, 2009·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hao ChengShuai Zhang
Nov 18, 2015·Journal of Translational Medicine·Chiara CugnoSergio Rutella
Mar 2, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lucille WoodPeter Jacobs

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