Successful Treatment With ATRA and Arsenic Trioxide for a Child With Down Syndrome and Acute Promyelocytic Leukemia

Journal of Pediatric Hematology/oncology
Yusuke TsumuraDaisuke Tomizawa

Abstract

Acute promyelocytic leukemia (APL) is rare in patients with Down syndrome (DS). Cytotoxic chemotherapy combined with all-trans retinoic acid (ATRA) has been a standard treatment for APL, but is potentially intolerable for DS patients because of their vulnerability to cytotoxic agents. We report here a case of a 10-year-old girl with DS and APL successfully treated with a combination of ATRA and arsenic trioxide, a therapy emerging as a new standard for APL. She achieved molecular remission and completed the therapy without significant toxicities. ATRA/arsenic trioxide combination therapy would be a preferable option for DS patients with APL.

References

Sep 1, 1987·Cancer Genetics and Cytogenetics·C T Fong, G M Brodeur
Mar 11, 2006·Cancer Genetics and Cytogenetics·Carla KurkjianMohamed A Kharfan-Dabaja
Nov 27, 2007·Journal of Medical Case Reports·Deepali JainPrerna Arora
Sep 26, 2008·Pediatric Blood & Cancer·Jessica Chow, James Feusner
Jul 29, 2009·Journal of Pediatric Hematology/oncology·Indranil GhoshVasantha Thavraj
Apr 8, 2011·British Journal of Haematology·Mayuko TsudaKohichiro Tsuji
Jul 12, 2013·The New England Journal of Medicine·Francesco Lo-CocoUNKNOWN Study Alliance Leukemia
Aug 22, 2016·Experimental and Molecular Pathology·Alejandro S MendozaJunchao Cai

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