Successful treatment with bosentan for refractory digital ulcers in a patient with systemic lupus erythematosus

The Journal of Dermatology
Yayoi NagaiOsamu Ishikawa

Abstract

We report a 32-year-old woman with a 12-year history of systemic lupus erythematosus. Physical examination revealed indurated plaques with small ulcers on her extremities and trunk, which were histologically diagnosed as lupus erythematosus profundus. On her arms and knees, multiple small calcified nodules were noted in the dermis and subcutis. An elevated level of anti-phosphatidylserine/prothrombin antibodies was noted. She had been suffering from digital ulcers on the left fourth finger. Despite conservative therapies, new ulcers appeared on other fingers. After the administration of bosentan, no new lesion has developed. Bosentan, recognized as a choice of treatments for digital ulcers in systemic sclerosis, is worth trying in systemic lupus erythematosus patients with refractory digital ulcers.

References

Mar 1, 1975·Archives of Dermatology·F P QuismorioS B Chandor
May 15, 2003·Arthritis and Rheumatism·Maureen D Mayes
May 4, 2005·Annals of Internal Medicine·Michael J SnyderKenneth S Knox
May 20, 2005·Clinical Rheumatology·Antonio G TristanoAlberto Millan
Nov 17, 2006·The British Journal of Dermatology·M HasegawaO Ishikawa
Jan 17, 2007·Archives of Dermatology·Melanie ChamaillardAlain Taïeb
Feb 1, 2007·Clinical and Experimental Dermatology·T YamamotoR Tsuboi

❮ Previous
Next ❯

Citations

Apr 7, 2011·Internal Medicine·Edoardo RosatoFelice Salsano
Nov 3, 2009·Seminars in Arthritis and Rheumatism·Amy Wasserman, Ernest Brahn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.