Successful Treatment with Cyclosporin A in Tocilizumab-resistant TAFRO Syndrome

Internal Medicine
Yusuke YamagaTakeshige Kunieda

Abstract

Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome is a unique clinicopathologic variant of multicentric Castleman's disease that has recently been identified in Japan. Previous reports have shown that affected patients typically respond to immunosuppressive therapy, such as prednisolone and tocilizumab. However, the optimal treatment for refractory TAFRO syndrome, which can be fatal, remains unclear. We herein report a case of tocilizumab-resistant TAFRO syndrome successfully treated with cyclosporin A, indicating that cyclosporine A may be an alternative therapy for refractory TAFRO syndrome.

References

Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
May 27, 1999·Seminars in Cancer Biology·E Cesarman, D M Knowles
Jul 5, 2005·Pathology, Research and Practice·Masaru KojimaNobuhide Masawa
May 24, 2008·International Journal of Surgical Pathology·Masaru KojimaShigeo Nakamura
Jun 27, 2013·Journal of Clinical and Experimental Hematopathology : JCEH·Noriko IwakiTadashi Yoshino

❮ Previous
Next ❯

Citations

Oct 13, 2017·Internal Medicine·Tatsuya AokiKeizo Kagawa
Jun 23, 2020·Pediatric Blood & Cancer·Shogo MinamikawaRyojiro Tanaka
Sep 24, 2020·Annals of Hematology·Mitsuhiro AkiyamaTsutomu Takeuchi
Oct 6, 2020·Case Reports in Rheumatology·Eiji SuzukiKiyoshi Migita
Sep 24, 2018·CEN Case Reports·Keiko HashimotoNorihiro Nakata
Dec 18, 2020·Internal Medicine·Sho ShibataToshiyuki Kitano
Nov 22, 2020·La Revue de médecine interne·J MaquetL Sailler
Oct 23, 2020·Modern Rheumatology Case Reports·Yuta YamaguchiAtsushi Kumanogoh
Aug 1, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Takashi YamaguchiNaomi Shimizu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.