Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report

BMC Cancer
Yu QiaoYao Wang

Abstract

Primary hepatic angiosarcoma (PHA) is a rare and aggressive solid tumor, with high rates of local recurrence and distant metastasis, and poor prognosis. There are no established treatment guidelines for PHA. A 78-year-old asymptomatic man with PHA that was successfully treated with pazopanib plus PD-1 inhibitor and RetroNectin-activated killer cells (RAK cells). After one month of treatment, there was a clear reduction in the size and number of the liver metastases; and after nearly 15 months, most of the lesions were stable, no new lesions had developed, and the side effect of treatment was minor. Pazopanib, PD-1 inhibitor and RAK cells could serve as a potential option for the treatment of advanced PHA.

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Citations

Feb 23, 2020·Japanese Journal of Clinical Oncology·Dong ZengBo Zhu
Nov 27, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Shaotao JiangNing Li
Jun 17, 2021·World Journal of Hepatology·Sang Jin KimJae-Won Joh

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Methods Mentioned

BETA
biopsy
surgical resection

Clinical Trials Mentioned

NCT02500797
NCT01472081

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