Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia

Progress in Neuro-psychopharmacology & Biological Psychiatry
Tadaaki KawanabeNobutaka Hattori

Abstract

To evaluate the efficacy and safety of Yokukansan, a traditional Chinese herbal medicine, for treating behavioral and psychological symptoms of dementia (BPSD) in patients with Parkinson disease (PD; n=7) and those with PD with dementia (PDD; n=7). BPSD are often seen in patients with senile dementia and have serious deleterious effects on the lives of patients and caregivers. Recent studies indicate that the traditional Chinese herbal medicine Yokukansan may be safe and beneficial for the treatment of BPSD patients. We treated 7 PD and 7 PDD patients for 4 weeks with Yokukansan and observed them without Yokukansan for 4 weeks. Changes in behavioral and psychological symptoms were evaluated every 4 weeks according to the Neuropsychiatric Inventory (NPI) scale. Significant improvements in behavioral and psychological symptoms, particularly in the incidence and duration of hallucinations, were observed in most PD and PDD patients after 4 weeks of Yokukansan treatment. No significant changes were observed in the laboratory tests, cognitive function, activities of daily living, or parkinsonism. Our results suggest that Yokukansan improves BPSD in both PD and PDD patients without worsening their cognitive function, ability to perfor...Continue Reading

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Citations

Apr 26, 2011·Chinese Medicine·Yuen-Shan HoRaymond Chuen-Chung Chang
Oct 31, 2013·Journal of Neural Transmission·Taku HatanoUNKNOWN Yokukansan Parkinson’s Disease Study Group
Oct 17, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Minoru TsujiHiroshi Takeda
Nov 11, 2011·CNS Neuroscience & Therapeutics·Elaine Perry, Melanie-Jayne R Howes
Mar 5, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Tsuyoshi MiyaokaJun Horiguchi
May 9, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Tsuyoshi MiyaokaHaruo Seno
Jul 16, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yoshihiko NakataniHiroshi Takeda
Jun 7, 2011·Drugs & Aging·Melanie-Jayne R Howes, Elaine Perry
Jan 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jung-Hee JangChangjong Moon
Sep 7, 2021·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
Feb 4, 2022·Aging & Mental Health·Katrina E WattsAnto P Rajkumar

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