PMID: 2496156Apr 1, 1989Paper

Successful use of aztreonam in a patient who failed oral penicillin desensitization

The Journal of Allergy and Clinical Immunology
R C LoriaH J Wedner

Abstract

A 69-year-old woman with Pseudomonas aeruginosa sepsis developed wheezing during the course of an oral penicillin desensitization. Despite treatment of the bronchospasm and readministration of the same dose of phenoxymethyl penicillin, wheezing recurred requiring stopping the desensitization procedure. Aztreonam, a monobactam antibiotic with activity against aerobic gram-negative bacilli, was administered along with an aminoglycoside. The patient tolerated a full course of aztreonam with no adverse reactions. This case report supports previous in vitro and in vivo studies, suggesting that aztreonam does not cross-react with penicillin-specific antibodies and that it may be well tolerated in beta-lactam-allergic individuals.

References

Aug 1, 1987·Annals of Internal Medicine·A SaxonD C Adelman
Feb 8, 1985·The American Journal of Medicine·R B Sykes, D P Bonner
Nov 1, 1985·Reviews of Infectious Diseases·R B Sykes, D P Bonner
Nov 1, 1985·Reviews of Infectious Diseases·N F AdkinsonE A Swabb
Jan 1, 1984·Antimicrobial Agents and Chemotherapy·N F AdkinsonA A Sugerman

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Citations

Mar 16, 2002·Current Allergy and Asthma Reports·K S Babu, Geeta Belgi
Feb 6, 2009·The Annals of Pharmacotherapy·Jane Frumin, Jason C Gallagher
Apr 6, 2006·Journal of the History of the Behavioral Sciences·Nancy D Campbell
Apr 1, 1990·Postgraduate Medicine·M A Volz, H S Nelson

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