Successful use of cyclosporin A in severe Schönlein-Henoch nephritis resistant to both methylprednisolone pulse and azathioprine.

Clinical Rheumatology
Jae Il ShinHyeon Joo Jeong

Abstract

Schönlein-Henoch nephritis (SHN) usually presents with micro-haematuria or mild proteinuria but can be associated with heavy proteinuria and nephrotic or acute nephritic syndrome. Although the treatment of SHN is still under debate, it has been suggested that cyclosporin A (CsA) may be beneficial in children with severe SHN, as reported by Ronkainen et al. (Pediatr Nephrol 18:1138-1142, 2003) and Someya et al. (Pediatr Int 46:111-113, 2004). However, histological effects of CsA on severe SHN had not been evaluated in their evaluations. We report the successful use of CsA in a male patient with severe SHN with nephrotic-range proteinuria, who failed to respond to methylprednisolone pulse and azathioprine therapy.

References

Feb 1, 1996·Journal of the American Society of Nephrology : JASN·S AmbalavananB D Myers
Jun 18, 1998·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P Niaudet, R Habib
Aug 13, 2002·Rheumatology International·Surjit SinghUsha Datta
Aug 21, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jaana RonkainenMatti Nuutinen
Mar 27, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Tomonosuke SomeyaYuichiro Yamashiro

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Citations

Dec 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marco Zaffanello, Vassilios Fanos
Jan 5, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Takeshi NinchojiMasafumi Matsuo
Jun 1, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Outi JauholaMatti Nuutinen
May 7, 2014·Case Reports in Medicine·Taylor Pindi SalaOlivier Lambotte
Nov 20, 2009·Current Rheumatology Reports·Abraham Gedalia, Raquel Cuchacovich
Sep 26, 2017·Internal Medicine·Naoki AkizueTetsuhiro Chiba

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