Successful use of recombinant activated factor VII (eptacog alfa, Novoseven®) in a refractory bleeding during pediatric cardiac surgery: a case report

JA Clinical Reports
Mariko IshiharaKeiko Kinouchi

Abstract

A 2-year-and-7-month-old boy underwent an emergent reconstruction surgery of the right ventricle-pulmonary artery (RV-PA) conduit. Although he was successfully weaned from cardiopulmonary bypass (CPB) after reconstruction of the RV-PA conduit, the bleeding continued despite the massive transfusion of red blood cell (RBC), fresh frozen plasma (FFP), and platelets. Because of persistent bleeding and abnormal coagulation laboratory results, we administered the recombinant activated factor VII (rFVIIa), which was not approved for use in the treatment of post-CPB coagulopathy. After administration of rFVIIa, his coagulation data dramatically improved, the bleeding decreased, and the operation was able to be finished.

References

Apr 15, 1972·British Medical Journal·R D BarrH M Cameron
Jan 7, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Troy E Dominguez, Kate L Brown
Nov 5, 2010·The New England Journal of Medicine·Marcel LeviDavid Truloff
Aug 13, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Magdalena Pychyńska-PokorskaJacek Jan Moll
Jun 2, 2012·Anesthesia and Analgesia·Nina A GuzzettaGlyn D Williams
Nov 20, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Danhua YaoJieshou Li

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Citations

Aug 26, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Rachel B CarrollNina A Guzzetta
Sep 5, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Shannon MorrisonPaul Davies

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Methods Mentioned

BETA
pulmonary artery plasty

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