Successful use of ReFacto continuous infusion in two paediatric patients with severe haemophilia A undergoing orthopaedic surgery

Haemophilia : the Official Journal of the World Federation of Hemophilia
M M Sennett, P A de Alarcón

Abstract

In this report we describe the successful use of B-domain-deleted recombinant factor VIII (ReFacto) administered by continuous infusion during orthopaedic procedures in two children with severe haemophilia A. Both patients underwent ankle synovectomy and in patient 2, a medial patello-femoral ligament repair was performed in the same operative session. Patient 2 developed septic arthritis A in his knee joint and arthroscopic joint irrigation and debridement was performed 2 weeks after the initial procedure. Surgical cover was initiated with a bolus dose of ReFacto 50 IU kg(-1) followed by continuous infusion at 3.3-4.8 IU kg(-1) h(-1) which was maintained for up to 9 days postoperatively. Patient 2 received an additional bolus dose of 15 IU kg(-1) during the infusion period. All procedures were performed without haemostatic complications and long-term orthopaedic outcomes were good in both patients.

References

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Feb 1, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·UNKNOWN United Kingdom Haemophelia Centre Doctors' Organisation
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Citations

Aug 5, 2006·Current Opinion in Hematology·Angelika Batorova, Uri Martinowitz
Jul 22, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-Merchan
Apr 4, 2012·Critical Reviews in Clinical Laboratory Sciences·Nigel G Laing

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