Successful uses of magnesium sulfate for torsades de pointes in children with long QT syndrome

Pediatrics International : Official Journal of the Japan Pediatric Society
Kenji HoshinoYoshikatsu Etoh

Abstract

Administration of magnesium sulfate (MgSO4) is an effective and safe treatment for torsades de pointes (TdP) associated with acquired long QT syndrome (LQTS) in adults. As for children, there are few reports focusing on it. The authors discuss the efficacy of MgSO4 for TdP in children with congenital and acquired LQTS. The authors also discuss the optimal administration dosage and serum magnesium (SMg) concentration during MgSO4 therapy. The authors studied seven consecutive LQTS children undergoing MgSO4 therapy for TdP. Of the seven children, five were congenital LQTS and two were acquired LQTS. A bolus injection of MgSO4 was given intravenously over 1-2 min followed by continuous infusion for the next 2-7 days. Of the seven patients, six responded completely to the initial bolus. The bolus dosage was 5.9 +/- 3.8 mg/kg (range, 2.3-12 mg/kg) in these six, and the other remaining one (neonate with congenital LQTS) required a total of 30 mg/kg until complete abolishment. The continuous infusion was given at rates of 0.3-1.0 mg/kg per h and patients did not show recurrence of TdP. The SMg concentration was 3.9 +/- 1.0 mg/dL (2.9-5.4 mg/dL) immediately after bolus injection. The mean corrected QT (QTc) interval before and after bo...Continue Reading

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Citations

Sep 26, 2008·Current Treatment Options in Cardiovascular Medicine·Gerald Serwer
Apr 23, 2011·International Journal of Hematology·Sachiko SasaseKeiichi Ozono
Feb 9, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Anders Rostrup NakstadKristina Hermann Haugaa
Jan 1, 2008·Annals of Pediatric Cardiology·Maully Shah, Christopher Carter
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Nov 10, 2013·Pediatric Emergency Care·Susan M SchrefflerJennifer Mackey

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