Abstract
Obesity and the metabolic syndrome (MetS) are risk factors for left ventricular diastolic dysfunction (LVDD). However, little is known about the impact of successful weight reduction (WR) on diastolic function and physical performance.Obese subjects (øBMI 40.2 ± 8.6 kg/m(2)) underwent a 1-year WR program comprising diet and lifestyle components. Echocardiography and exercise capacity (6-minute walk) were performed at baseline and after 1 year. The distribution of weight reduction was split at the sample median and subjects were dichotomized in "successful WR" (% WR ≥ median, corresponding to a weight loss of 8%) and "failed-WR" (% WR < median).From a total of 188 obese subjects, 71 had LVDD at baseline. Obese patients with successful WR improved their MetS alterations, including fasting glucose, insulin, lipids, adipokines, blood pressure levels, and epicardial fat thickness. The same was not true for obesity with failed WR. Subjects with successful WR demonstrated significant improvement in echocardiographic LVDD parameters (median [interquartile range]): Δe' (2,5 [-1.0, 4.7], P < 0.01), Δe'/a' (0.34 [0.07, 079], P < 0.01), ΔE/e' (-1.14 [-2.72, -0.54], P < 0.05), ΔE/A (0.08 [-0.04, 0.26], P < 0.05), ΔArd-Ad (-28 [-54, -4], P <...Continue Reading
References
Dec 1, 1995·The American Journal of Cardiology·M A AlpertV Mukerji
Dec 1, 1995·Journal of the American College of Cardiology·R S VasanD Levy
Nov 15, 1997·BMJ : British Medical Journal·K KarasonL Sjöström
Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
Sep 18, 2001·JAMA : the Journal of the American Medical Association·A H MokdadJ P Koplan
Oct 12, 2001·Obesity Surgery·E KanoupakisJ Melissas
Aug 2, 2002·The New England Journal of Medicine·Satish KenchaiahRamachandran S Vasan
Feb 13, 2003·European Heart Journal·M FischerH Schunkert
Apr 20, 2004·Journal of the American College of Cardiology·Linda R PetersonVíctor G Dávila-Román
May 7, 2004·The New England Journal of Medicine·Michael R ZileWilliam H Gaasch
Jun 15, 2004·The American Journal of Cardiology·Maria E OttoVirend Somers
Nov 3, 2004·Circulation·Chiew Y WongThomas H Marwick
Nov 3, 2004·Circulation·Robert H EckelUNKNOWN American Heart Association
Jun 14, 2005·The American Journal of Cardiology·Howard J WillensMaureen H Lowery
Sep 27, 2005·European Heart Journal·N F MurphyJ J V McMurray
Sep 28, 2005·Nature Clinical Practice. Cardiovascular Medicine·Gianluca IacobellisArya M Sharma
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Aug 22, 2006·Lancet·Abel Romero-CorralFrancisco Lopez-Jimenez
Dec 6, 2006·The American Journal of Cardiology·Chiew Y WongThomas H Marwick
Apr 13, 2007·European Heart Journal·Walter J PaulusDirk L Brutsaert
Jul 27, 2007·Nature Clinical Practice. Cardiovascular Medicine·Chiew Wong, Thomas H Marwick
Nov 24, 2007·Diabetes, Obesity & Metabolism·M R SkiltonD S Celermajer
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Mar 10, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sherif F NaguehArturo Evangelisa
Mar 20, 2009·The New England Journal of Medicine·Kirsten Bibbins-DomingoStephen B Hulley
Jun 10, 2009·Circulation·Douglas S LeeDaniel Levy
Jul 18, 2009·Circulation Research·Valéria Lamounier-ZepterIngo Morano
Aug 15, 2009·Journal of the American College of Cardiology·Oliver J RiderStefan Neubauer
Dec 1, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Gianluca Iacobellis, Howard J Willens
Feb 2, 2010·Angiology·Anand ChockalingamTom R Thomas
Oct 12, 2010·JAMA : the Journal of the American Medical Association·Bret H GoodpasterJohn M Jakicic
Feb 4, 2011·The American Journal of Clinical Nutrition·Stefanie B MurerMichael B Zimmermann
Jan 21, 2012·Circulation·Wael AljaroudiWael A Jaber
May 11, 2012·Journal of Hypertension·Jens JordanNick Finer
Jul 31, 2012·European Journal of Heart Failure·Andrea BaesslerMarcus Fischer
Sep 18, 2012·The American Journal of Cardiology·João L CavalcanteThomas H Marwick
Nov 7, 2012·Journal of Consulting and Clinical Psychology·Daniel S Kirschenbaum, Kristen Gierut
Dec 28, 2012·The International Journal of Cardiovascular Imaging·O J RiderS Neubauer
Jan 30, 2013·Diabetes Care·Richard R RubinUNKNOWN Look AHEAD Research Group
Feb 16, 2013·The American Journal of Medicine·Jessica L UnickUNKNOWN Look AHEAD Research Group
Citations
Dec 1, 2015·Expert Opinion on Therapeutic Targets·Andrew Jm LewisOliver J Rider
Jan 9, 2016·International Heart Journal·Yasunaga ShiraishiTakeshi Adachi
Jul 18, 2015·Progress in Cardiovascular Diseases·Arthur R MenezesFreddy M Abi-Samra
Aug 11, 2016·Metabolism: Clinical and Experimental·Juan Serrano-FerrerPhilippe Obert
Jun 9, 2016·Korean Circulation Journal·JinShil KimMi-Seung Shin
Jul 12, 2016·International Heart Journal·Judith ZellerAndrea Baessler
Aug 3, 2016·Korean Circulation Journal·Shin Yi JangSang-Chol Lee
Oct 16, 2016·Journal of the American College of Cardiology·Jeffrey I MechanickW Timothy Garvey
Oct 21, 2016·Cardiovascular Drugs and Therapy·Catarina FranciscoAdelino Leite-Moreira
Apr 8, 2018·Current Medical Research and Opinion·Christos A GoudisTong Liu
Sep 3, 2019·Clinical Obesity·Evan AtlantisNic Kormas
Dec 24, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tae-Min RheeMyung-A Kim
Dec 19, 2019·European Journal of Heart Failure·Milton Packer
Feb 10, 2020·Lipids in Health and Disease·Yu Si YaoZhi Huan Zeng
Sep 22, 2020·Circulation·Muhammad Shahzeb KhanJaved Butler
Feb 7, 2018·Sudebno-meditsinskaia ekspertiza·Yu I PigolkinD V Gornostaev
Oct 5, 2017·PloS One·Mi-Seung ShinJinShil Kim
Apr 15, 2021·Obesity Research & Clinical Practice·Sabine J M SagAndrea Baessler
Oct 18, 2019·The American Journal of Medicine·Milton Packer
Oct 1, 2021·Lipids in Health and Disease·Xunwei DengZhixiong Zhong