Jan 29, 1965

SUCCESSIVE TRANSFORMATIONS OF AN ESTABLISHED CELL LINE BY POLYOMA VIRUS AND SV40

Science
G J Todaro, H Green

Abstract

Two different oncogenic viruses, polyoma and SV40, are capable of transforming mouse cell line 3T3. The properties of the transformed cells produced by the two viruses are in some ways similar, but in other ways they are specific for the infecting virus. This fact permits testing whether a cell line transformed by the one oncogenic virus is still susceptible to the transforming action of the second virus. Two different clonally isolated polyoma-transformed lines when infected with SV40 give rise to cells with properties characteristic of SV40-transformed cells. The frequency of transformation, however, is considerably reduced compared to that of the parent cell line, 3T3.

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Mentioned in this Paper

Oncogenic Viruses
Simian virus 40
Mouse Cell Line
Fibroblasts
Tissue Culture Techniques
Metaplastic Cell Transformation
Cell Transformation
Murine polyomavirus
Established Cell Line
Polyomavirus

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