Succinic acid production on xylose-enriched biorefinery streams by Actinobacillus succinogenes in batch fermentation

Biotechnology for Biofuels
Davinia SalvachúaGregg T Beckham

Abstract

Co-production of chemicals from lignocellulosic biomass alongside fuels holds promise for improving the economic outlook of integrated biorefineries. In current biochemical conversion processes that use thermochemical pretreatment and enzymatic hydrolysis, fractionation of hemicellulose-derived and cellulose-derived sugar streams is possible using hydrothermal or dilute acid pretreatment (DAP), which then offers a route to parallel trains for fuel and chemical production from xylose- and glucose-enriched streams. Succinic acid (SA) is a co-product of particular interest in biorefineries because it could potentially displace petroleum-derived chemicals and polymer precursors for myriad applications. However, SA production from biomass-derived hydrolysates has not yet been fully explored or developed. Here, we employ Actinobacillus succinogenes 130Z to produce succinate in batch fermentations from various substrates including (1) pure sugars to quantify substrate inhibition, (2) from mock hydrolysates similar to those from DAP containing single putative inhibitors, and (3) using the hydrolysate derived from two pilot-scale pretreatments: first, a mild alkaline wash (deacetylation) followed by DAP, and secondly a single DAP step, ...Continue Reading

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Citations

May 18, 2016·Bioresource Technology·Davinia SalvachúaGregg T Beckham
Jun 4, 2016·Journal of Industrial Microbiology & Biotechnology·Henrik AlmqvistGunnar Lidén
Oct 21, 2016·Applied Microbiology and Biotechnology·Michael F A Bradfield, Willie Nicol
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Methods Mentioned

BETA
reverse-phase chromatography

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