Succinylcholine Is Associated with Increased Mortality When Used for Rapid Sequence Intubation of Severely Brain Injured Patients in the Emergency Department

Pharmacotherapy
Asad E PatanwalaJohn C Sakles

Abstract

To compare succinylcholine and rocuronium regarding mortality in patients with traumatic brain injury (TBI) who are intubated in the emergency department (ED). This was a retrospective cohort study conducted in an academic ED in the United States. Adult patients with TBI who underwent rapid sequence intubation (RSI) in the ED with rocuronium or succinylcholine between October 2010 and October 2014 were included. The main outcome of interest was in-hospital mortality. Subjects were stratified based on severity of injury using head abbreviated injury scores. The high-severity group had a severe or critical head injury (score 4 or higher); the low-severity group had a less than severe head injury (score lower than 4). The final study cohort included 233 patients who were underwent RSI with succinylcholine (149 patients) or rocuronium (84 patients). In patients who received rocuronium, mortality was 22% (12/54) and 23% (7/30) in the low-severity and high-severity categories, respectively (difference 1%, 95% confidence interval [CI] -18% to 20%). In patients who received succinylcholine, mortality was 14% (14/103) and 44% (20/46) in the low-severity and high-severity categories, respectively (difference 30%, 95% CI 14-46). In the mu...Continue Reading

References

Jul 18, 2002·Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention·V BarellR Heruti
Oct 20, 2004·Archives of Surgery·Demetrios DemetriadesLinda S Chan
Nov 29, 2008·Stroke; a Journal of Cerebral Circulation·Simona SaccoAntonio Carolei
Dec 25, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Asad E PatanwalaBrian L Erstad
Nov 10, 2012·Emergency Medicine Journal : EMJ·John M WattAsad E Patanwala
Mar 21, 2013·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Justin D KorinekAsad E Patanwala
Aug 15, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Albert AminiAsad E Patanwala

❮ Previous
Next ❯

Citations

Jun 1, 2016·The American Journal of Emergency Medicine·Reuben J Strayer
Sep 18, 2018·Anesthesiology·James E Cottrell
Sep 16, 2017·Neurocritical Care·Venkatakrishna RajajeeDavid B Seder
Dec 15, 2018·Anesthesiology·Marilyn Green LarachUNKNOWN Multicenter Perioperative Outcomes Group
Aug 9, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Nicole M AcquistoMichael C Thomas
Oct 22, 2020·Trauma Surgery & Acute Care Open·Carlos V R BrownMatthew Martin
Feb 11, 2021·Anesthesiology Clinics·Kelsey Serfozo, Vijay Tarnal
Nov 22, 2020·Emergency Medicine Clinics of North America·Kyle M DeWitt, Blake A Porter
Apr 27, 2021·Neurologic Clinics·Anil RamineniAla Nozari
Jun 28, 2020·The Journal of Emergency Medicine·Skyler LentzBrit Long

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
E G LaurinJ Redd
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Asad E PatanwalaJohn C Sakles
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Asad E PatanwalaBrian L Erstad
© 2022 Meta ULC. All rights reserved