PMID: 8944383Dec 1, 1996Paper

Sucralfate and basic fibroblast growth factor promote endothelial cell proliferation around porous alloplastic implants in vitro

Ophthalmic Plastic and Reconstructive Surgery
T E NicaeusP A Rubin

Abstract

Enhanced ingrowth of fibrovascular tissue into alloplastic orbital implants is clinically desirable. Basic fibroblast growth factor (bFGF) is an angiogenic factor that promotes proliferation of endothelial cells. Sucralfate is known to bind bFGF and render it stable by protecting it from degradation. To test the ability of bFGF to stimulate endothelial cell proliferation, porous orbital implants coated with a sustained-release and bioactively-stabilized preparation of the angiogenic peptide bFGF were studied. Hydroxyapatite (HA) and porous polyethylene (PP) implant discs (15 x 3 mm) were coated with sustained-release polymer polyhydroxyethylmethacrylate (hydron), sucralfate (a bFGF stabilizer), hydron plus or hydron/sucralfate plus bFGF. Discs were placed in tissue culture wells plated with 50,000 endothelial cells/well. After 5 days, cells were trypsinized and counted electronically using a Coulter counter. Statistical analysis was performed using unpaired Student's t-test. Implant discs coated with hydron/sucralfate/bFGF had significantly increased endothelial cell proliferation compared to discs coated with hydron alone or hydron/sucralfate (p < 0.05). There was no significant difference in the degree of enhanced proliferati...Continue Reading

Citations

Nov 23, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Byung Woo ParkTae Soo Lee
Jun 6, 2000·Advanced Drug Delivery Reviews· Mark Saltzman W, S P Baldwin
Aug 30, 2007·Journal of Zhejiang University. Science. B·Hong-guang Cui, Hui-yan Li
Dec 19, 2014·Journal of Gastroenterology and Hepatology·Sandor Szabo
Jul 31, 2001·Ophthalmic Plastic and Reconstructive Surgery·J D NgA D Elkins
Oct 6, 2000·Ophthalmic Plastic and Reconstructive Surgery·C N SoparkarD Appling
Oct 30, 2007·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Toru GamoMasa-Aki Hattori
Jun 25, 2010·Clinical & Experimental Ophthalmology·Sul-Gee LeeYoung-Il Yang
May 15, 2013·Science and Technology of Advanced Materials·Xiupeng WangJiandong Ye

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