Sucralfate suppresses Helicobacter pylori infection and reduces gastric acid secretion by 50% in patients with duodenal ulcer

Gastroenterology
S BanerjeeK E McColl

Abstract

The mechanism(s) by which sucralfate heals duodenal ulcers remains unclear. The aim of this study was to determine the effect of sucralfate on Helicobacter pylori infection and on the accompanying hypersecretion of gastric acid the infection induces in patients with duodenal ulcer. Basal and gastrin-releasing peptide (GRP) stimulated gastrin release and acid secretion. H. pylori density, gastric urease activity, and severity of gastritis were studied in patients with duodenal ulcer who were positive for H. pylori before, during, and after 4 weeks' treatment with sucralfate (2 g twice daily). The density of H. pylori decreased by 70% during sucralfate treatment and returned to the pretreatment level after discontinuation of therapy. This suppression of H. pylori infection was accompanied by an 80% decrease in gastric urease activity. GRP-stimulated plasma gastrin concentrations, GRP-stimulated acid output, and basal acid output all decreased by approximately 50% during sucralfate therapy and returned to pretreatment levels after treatment was discontinued. These findings indicate that sucralfate markedly suppresses H. pylori infection and the accompanying hypersecretion of acid the infection induces in patients with duodenal ulc...Continue Reading

Citations

Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Koichiro WatanabeToshio Fujioka
Jul 7, 2009·Annual Review of Physiology·John P Geibel, Steven C Hebert
Oct 6, 1998·Scandinavian Journal of Gastroenterology·B L SlomianyA Slomiany
Jul 1, 2006·Chinese Journal of Digestive Diseases·Yan SunXiao Hua Hou
Apr 3, 2008·The Journal of Pharmacy and Pharmacology·Rethinam Sundaresan DeviChennam Srinivasulu Shyamala Devi
Apr 18, 1998·Gastroenterology Clinics of North America·M S Cappell, A Garcia
Dec 20, 2011·Digestive Diseases·M Varbanova, P Malfertheiner
Jul 1, 2004·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Peter Z RashevMartin P Mintchev
Aug 18, 2009·Lancet·Peter MalfertheinerKenneth E L McColl
Jan 16, 2003·The American Journal of Gastroenterology·Britta DickhausBruce D Naliboff
Sep 19, 2000·Journal of Clinical Gastroenterology·F H NgB C Wong
Oct 21, 2015·BMC Complementary and Alternative Medicine·Yarasi Gayathri RamakrishnaSivasitamparam Niranjali Devaraj
May 24, 2006·World Journal of Gastroenterology : WJG·P Kirchhoff, J-P Geibel
Mar 15, 2003·Gastroenterology Clinics of North America·Mitchell S Cappell

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