PMID: 8603220Mar 1, 1996Paper

Sucrose as an analgesic agent for infants during immunization injections

Archives of Pediatrics & Adolescent Medicine
K D AllenJ N Walburn

Abstract

To assess the effectiveness of sucrose as an analgesic agent during routine immunization injections for infants (age range, 2 weeks to 18 months). Double-blind, randomized control trial. Ambulatory care clinic of a large tertiary care center. A consecutive sample of 285 infants were randomly assigned to one of three treatment groups. Subjects received either no intervention or drank 2 mL of sterile water or 2 mL or a 12% sucrose solution 2 minutes before administration of the immunization. Infants were videotaped during immunization for later interval recording of pain-induced vocalizations. Results were analyzed by using two-way repeated measure analyses of variance. Two-week-old infants who received either the sterile water or sucrose solution cried significantly less than infants who received no intervention (F=5.92,P<.005). For older infants, those who received water or sucrose cried significantly less only if they were administered one injection rather than two injections (F=3.36,P<.05). We found that when infants drank sucrose or sterile water, significantly fewer pain vocalizations were produced, but only for 2-week-old infants. For older infants, differences were found only when the number of injections was included in ...Continue Reading

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