Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment

International Journal of Legal Medicine
Vittorio FineschiEmanuela Turillazzi

Abstract

The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before. He had a history of treatment-resistant chronic schizophrenia. A complete immunohistochemical study was performed on heart specimens. Histologically, the heart presented diffuse eosinophilic infiltrates located around perivascular structures and focal myocyte necrosis with numerous interstitial eosinophils admixed with histiocytes. The diagnosis of acute myocarditis with an eosinophilic infiltrate was established as the cause of death. The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.

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Citations

Dec 22, 2005·International Journal of Legal Medicine·H PfeifferJ Beike
Apr 1, 2006·Indian Journal of Psychiatry·Kuruvilla ThomasK K Jayaprakash
Mar 8, 2005·International Journal of Legal Medicine·Cristoforo PomaraVittorio Fineschi
Oct 29, 2005·International Journal of Legal Medicine·H PfeifferB Brinkmann
Apr 20, 2005·International Journal of Cardiology·Giorgio BaroldiVittorio Fineschi
Sep 20, 2005·International Journal of Cardiology·E TurillazziV Fineschi
Jul 15, 2015·Journal of Forensic and Legal Medicine·Rakesh K SewalBikash Medhi
Apr 14, 2015·Acta Psychiatrica Scandinavica·K J RonaldsonJ J McNeil
Nov 29, 2005·International Journal of Cardiology·Cristoforo PomaraVittorio Fineschi
May 26, 2016·Current Psychiatry Reports·Martina CurtoRoss J Baldessarini
Dec 19, 2015·International Journal of Psychiatry in Medicine·Nitin Chopra, Jose de Leon
Jan 16, 2010·Journal of Clinical Psychopharmacology·Marina GrgasCharles F Caley
Apr 20, 2018·Frontiers in Neuroscience·Jessica W Y YuenAlasdair M Barr
Dec 23, 2016·The American Journal of Forensic Medicine and Pathology·Mehdi Ben KhelilMoncef Hamdoun

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