Sudden Cardiac Death: Pharmacotherapy and Proarrhythmic Drugs: A Nationwide Cohort Study in Denmark

JACC. Clinical Electrophysiology
Bjarke RisgaardJacob Tfelt-Hansen

Abstract

This study sought to describe the use of pharmacotherapy in a nationwide cohort of young patients with sudden cardiac death (SCD). Several drugs have been associated with an increased risk of SCD and sudden arrhythmic death syndrome (SADS). It remains unclear how pharmacotherapy may contribute to the overall burden of SCD in the general population. This was a nationwide study that included all deaths that occurred between 2000 and 2009 and between 2007 and 2009 in people age 1 to 35 years and 36 to 49 years, respectively. Two physicians identified all SCDs through review of death certificates. Autopsy reports were collected. Pharmacotherapy prescribed within 90 days before SCD was identified in the Danish Registry of Medicinal Product Statistics. We identified 1,363 SCDs; median age was 38 years (interquartile range: 29 to 45 years), and 72% (n = 975) were men. Autopsy was performed in 55%. Overall, 58% of SCD cases (n = 786) received at least 1 drug within 90 days before death. The most common drugs were analgesic drugs (n = 239; 18%), antihypertensive drugs (n = 234; 17%), and antibiotic drugs (n = 218; 16%). After multivariable adjustment, prescription of "brugadogenic" drugs or >1 QT-prolonging drug was associated with an i...Continue Reading

References

Nov 15, 1997·Journal of the American College of Cardiology·J J de Vreede-SwagemakersH J Wellens
Oct 31, 2001·Circulation·Z J ZhengG A Mensah
Nov 3, 2001·The American Journal of Psychiatry·A H Glassman, J T Bigger
Jan 12, 2002·JAMA : the Journal of the American Medical Association·Mark OlfsonHarold Alan Pincus
Mar 5, 2004·The New England Journal of Medicine·Dan M Roden
Mar 17, 2004·Journal of Clinical Epidemiology·S M J M StrausM C J M Sturkenboom
May 26, 2004·Pain·Margaret A Caudill-SlosbergSteven Woloshin
Jan 26, 2006·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Rajender R AparasuSanjay Gupta
Feb 21, 2006·Journal of the American College of Cardiology·David J TesterMichael J Ackerman
Jan 16, 2009·The New England Journal of Medicine·Wayne A RayC Michael Stein
Jan 16, 2009·The New England Journal of Medicine·Sebastian Schneeweiss, Jerry Avorn
Mar 14, 2009·Journal of the American College of Cardiology·William WhangChristine M Albert
Sep 1, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Pieter G PostemaArthur A M Wilde
Nov 18, 2009·British Journal of Clinical Pharmacology·Kate JollyMichael J S Langman
Feb 27, 2010·Journal of the American College of Cardiology·Barbara J DrewUNKNOWN American College of Cardiology Foundation
Dec 7, 2010·European Heart Journal·Bo Gregers WinkelJacob Tfelt-Hansen
Aug 4, 2011·Scandinavian Journal of Public Health·Elsebeth LyngeMatejka Rebolj
Aug 4, 2011·Scandinavian Journal of Public Health·Helle Wallach KildemoesJesper Hallas
May 17, 2012·Clinical Pharmacology and Therapeutics·P WeekeC Torp-Pedersen
Oct 24, 2012·European Heart Journal·Elijah R Behr, Dan Roden
Dec 18, 2013·European Heart Journal·Bo Gregers WinkelJacob Tfelt-Hansen
Mar 8, 2014·Circulation. Arrhythmia and Electrophysiology·Bjarke RisgaardJacob Tfelt-Hansen
Mar 20, 2014·European Heart Journal·Søren FanoeHenning Bundgaard
Jun 25, 2014·Clinical Pharmacology and Therapeutics·P WeekeC Torp-Pedersen
Jan 24, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bjarke RisgaardJacob Tfelt-Hansen
Nov 14, 2015·Journal of the American College of Cardiology·Yun-Jiu ChengSu-Hua Wu

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Citations

Mar 3, 2020·JAMA Internal Medicine·Timothy F SimpsonZian H Tseng
Jan 10, 2020·International Journal of Legal Medicine·Sara SabatassoKatarzyna Michaud
Mar 23, 2021·Journal of the American Heart Association·Vilde Waaler LolandJacob Tfelt-Hansen

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