Sudden death in epilepsy, surgery, and seizure outcomes: the interface between heart and brain

Cleveland Clinic Journal of Medicine
Lara Jehi

Abstract

A significant body of literature suggests that sudden unexpected death in epilepsy (SUDEP) has a cardiac mechanism. Although a correlation has been established between freedom from seizures and reduced SUDEP risk, the exact relationship between seizure outcomes following epilepsy surgery and SUDEP is still being studied. Emerging evidence suggests that seizure outcomes following epilepsy surgery and risk for SUDEP may both be governed by a common underlying biologic process linked to cardiac changes and autonomic dysregulation.

Citations

Jul 9, 2011·Lancet·Simon Shorvon, Torbjorn Tomson
Jun 21, 2014·Pharmacological Reports : PR·Kinga K Borowicz, Monika Banach
Nov 19, 2013·Expert Review of Neurotherapeutics·Gauhar A Malik, Phil E M Smith
Jul 2, 2014·Epilepsy & Behavior : E&B·Kenneth D LaxerSelim R Benbadis
Aug 4, 2016·Arquivos de neuro-psiquiatria·Fulvio A ScorzaJaderson Costa da Costa
Jan 14, 2012·British Journal of Hospital Medicine·Sukhjinder S Nijjer, David C Lefroy

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