Sudden Death in Patients With Severe Aortic Stenosis: Observations From the CURRENT AS Registry

Journal of the American Heart Association
Tomohiko TaniguchiCURRENT AS registry Investigators

Abstract

The annual incidence of sudden death has been reported to be low (<1%/year) in asymptomatic patients with severe aortic stenosis (AS), and there is a paucity of data on the risk factors of sudden death in patients with severe AS. We evaluated the incidence and risk factors of sudden death during the median follow-up period of 1334 days in the Contemporary Outcomes After Surgery and Medical Treatment in Patients With Severe Aortic Stenosis (CURRENT AS) registry enrolling 3815 consecutive patients with severe AS between 2003 and 2011. The mean age was 78 years, and the prevalences of male sex and prior myocardial infarction were 38% and 8%, respectively. Sudden death occurred in 175 patients without aortic valve replacement. The cumulative 5-year incidences of sudden death, censored at aortic valve replacement, which accounted for the competing risk, were 9.2% in symptomatic patients and 7.2% (1.4%/year) in asymptomatic patients (P<0.001). Among 82 asymptomatic patients experiencing sudden death, 54 patients (66%) died abruptly without any preceding symptoms, and 35 (65%) of these sudden deaths occurred within 3 months of the last clinical follow-up visit. Independent risk factors for sudden death were hemodialysis (hazard ratio ...Continue Reading

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Citations

Oct 6, 2018·Expert Review of Cardiovascular Therapy·Sveeta BadianiSanjeev Bhattacharyya
Jul 12, 2019·Internal Medicine Journal·Julia Isbister, Christopher Semsarian
Dec 4, 2019·Journal of Medical Ultrasonics·Takeshi Kitai, Rayji S Tsutsui
Sep 24, 2020·Journal of the American Heart Association·Yohann BohbotChristophe Tribouilloy
Jun 12, 2020·Heart·Bharat Khialani, Philip MacCarthy
Aug 7, 2019·European Heart Journal. Quality of Care & Clinical Outcomes·Eri Minamino-MutaTakeshi Kimura
Aug 2, 2020·Heart·Jan MinnersNikolaus Jander
Jan 18, 2021·The American Journal of Cardiology·Martín ValdebenitoAmit Segev
Nov 6, 2020·Heart·Rong Bing, Marc Richard Dweck
Apr 4, 2021·Journal of Cardiovascular Development and Disease·Mevlüt ÇelikAd J J C Bogers
Mar 28, 2021·Clinical Imaging·Giancarlo SavinoRiccardo Marano
Jun 30, 2021·Heart Failure Reviews·Grigorios GiamouzisFilippos Triposkiadis
Jul 3, 2021·International Journal of Molecular Sciences·Laura Mourino-AlvarezMaria G Barderas
Jun 18, 2021·BioMed Research International·Adelaide IervolinoFrancesco Nappi
Sep 30, 2021·JAMA Cardiology·Augustin CoisneUNKNOWN VALVENOR Investigators

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Methods Mentioned

BETA
dissection
coronary artery bypass

Clinical Trials Mentioned

NCT03042104

Software Mentioned

JMP
SAS

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