Sudden enlargement of local recurrent thyroid tumor after recombinant human TSH administration

The Journal of Clinical Endocrinology and Metabolism
M BragaDavid S Cooper


Chronic endogenous TSH stimulation of neoplastic tissue has been reported to stimulate tumor enlargement. However, little is known about changes in normal and neoplastic thyroid tissue after sudden rather than chronic stimulation with TSH. Acute thyroidal tissue reactions, reflected by rapid tumor expansion and/or possible vascular changes, have been reported to occur after bovine TSH stimulation and, more recently, after recombinant human TSH (rhTSH). In this report, we describe two patients with papillary thyroid carcinoma with local recurrent tumor. Both patients developed tumor growth 12-48 h after the second rhTSH injection, reflected by acute respiratory distress or a palpable, tender mass. In both situations, the enlargement was documented by imaging techniques, showing tumor expansion compared with previous examinations. Rapid improvement with glucocorticoid supports inflammation as the likely etiology. Based on these cases, and other reports of rapid tumor expansion after rhTSH injection, we recommend glucocorticoid coverage before rhTSH administration for patients with known or suspected neoplasia located in a limited space.


Jan 1, 2009·F1000 Medicine Reports·Ulla Feldt-Rasmussen
Oct 14, 2008·Expert Opinion on Biological Therapy·Gilberto J Paz-Filho, Hans Graf
Jan 27, 2006·Expert Opinion on Biological Therapy·Marius E Kraenzlin, Christian Meier
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Christoph ReinersMarkus Luster
Jun 9, 2012·Journal of Veterinary Internal Medicine·M CamposS Daminet
May 18, 2010·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Miguel CamposSylvie Daminet
Oct 27, 2016·Medical Physics·Pablo MínguezKatarina Sjögreen Gleisner
Jun 25, 2002·The American Journal of Medicine·Milena BasariaDavid S Cooper
Jan 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Sophie LeboulleuxPaul W Ladenson
Jun 22, 2005·Current Treatment Options in Oncology·Richard T Kloos
Aug 22, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Martin SchlumbergerFurio Pacini
Jan 21, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Paolo Zanotti-FregonaraDomenico Rubello
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Steen J BonnemaLaszlo Hegedüs
Nov 29, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Joanna Klubo-GwiezdzinskaLeonard Wartofsky
Aug 3, 2002·Clinical Endocrinology·Fabián Pitoia, Hugo Niepomniszcze
Jan 22, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Charles H Emerson, Mira S T Torres
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Hans Graf, Gilberto Paz-Filho

❮ Previous
Next ❯

Related Concepts

Related Feeds


Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.