PMID: 9160285Apr 1, 1997Paper

Sudden infant death syndrome and placental disorders: the thyroid-selenium link

Medical Hypotheses
G M Reid, H Tervit

Abstract

Placental insufficiency, inducing hypoxia-ischaemia, is considered a major cause of neuronal injury and impaired post natal development. Placental insufficiency alters the metabolism of arachidonic acid and its oxidation products. Premature labour and low-birth-weight infants are associated with reduced intrauterine blood-flow and infections of the reproductive tract. Thyroidal activity is depressed in undernutrition (placental insufficiency). Premature infants require extra vitamin C for normal tyrosine metabolism (tyrosine is the thyroxine precursor). Among the symptoms indicating infantile cretinism, which appear during 3-5 months of age are: delayed union of skull bones, torpid behaviour, slow feeding, cyanosis during feeding, excessive sleepiness, enlarged tongue, umbilical herniation, flabby musculature, short stature and delayed development. These symptoms have all been described in low-birth-weight infants and sudden infant death syndrome victims by various authors. Bacteria utilize selenium (at the expense of host tissue). Escherichia coli is among the bacteria invading the reproductive tract. E. coli produce thiouracil and are goitrogenic. Some strains of E. coli produce phospholipase A2 which releases arachidonic aci...Continue Reading

References

Feb 1, 1976·Biochemical Pharmacology·R J Flower, G J Blackwell
Jun 1, 1977·The Journal of Pediatrics·R L NaeyeC Marboe
Nov 1, 1976·American Journal of Diseases of Children·R L NaeyeJ S Drage
Sep 1, 1992·The American Journal of Forensic Medicine and Pathology·G MolzB Vonlanthen
Jan 1, 1990·Annals of the New York Academy of Sciences·R J MilnerJ G Sutcliffe
Jan 1, 1991·Annals of the New York Academy of Sciences·M D Ard, A Faissner
Jan 1, 1991·Annals of the New York Academy of Sciences·R P Skoff, P E Knapp
Jan 1, 1989·Annals of the New York Academy of Sciences·P ReddannaC C Reddy
Jan 1, 1989·Annals of the New York Academy of Sciences·N G Bazan
Jan 1, 1989·Annals of the New York Academy of Sciences·E YavinS Harel
Mar 5, 1987·The New England Journal of Medicine·D A GreeneA A Sima
Jan 1, 1988·Annals of the New York Academy of Sciences·J B Beckwith
Nov 29, 1973·The New England Journal of Medicine·R L Naeye
Mar 8, 1974·Science·T C Stadtman
Mar 15, 1974·Science·M J SilverJ B Smith
Apr 15, 1983·Experientia·T MasukawaH Iwata
Oct 1, 1983·Medical Hypotheses·G M Reid
Mar 1, 1984·Journal of Clinical Pathology·S Variend, R Sunderland
Dec 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·V S Steele, J A Froseth
Apr 21, 1995·Annals of the New York Academy of Sciences·G A Rodan
Apr 21, 1995·Annals of the New York Academy of Sciences·D T DenhardtS E Walther
Jul 7, 1995·Annals of the New York Academy of Sciences·J R RichertC K Hurley
Aug 27, 1993·Annals of the New York Academy of Sciences·D R ClemmonsG Wright
Aug 27, 1993·Annals of the New York Academy of Sciences·D Prager, S Melmed
Aug 27, 1993·Annals of the New York Academy of Sciences·A J D'Ercole
Aug 27, 1993·Annals of the New York Academy of Sciences·F A McMorrisN Marchetti

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Citations

Sep 29, 1998·Critical Care Medicine·P G Haji-Michael, J L Vincent
Dec 25, 2007·Chemico-biological Interactions·K K KabirovA V Lyubimov
Sep 25, 2004·Head & Neck·Ioannis E PetrakisGeorgios E Chalkiadakis
May 29, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Darios GetahunGeorge G Rhoads
Apr 23, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·Mohammad SaadatniaGilda Kinani Mehr

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