Sudden sensorineural hearing loss and polymorphisms in iron homeostasis genes: new insights from a case-control study

BioMed Research International
Alessandro CastiglioneDonato Gemmati

Abstract

Background. Even if various pathophysiological events have been proposed as explanations, the putative cause of sudden hearing loss remains unclear. Objectives. To investigate and to reveal associations (if any) between the main iron-related gene variants and idiopathic sudden sensorineural hearing loss. Study Design. Case-control study. Materials and Methods. A total of 200 sudden sensorineural hearing loss patients (median age 63.65 years; range 10-92) were compared with 400 healthy control subjects. The following genetic variants were investigated: the polymorphism c.-8CG in the promoter of the ferroportin gene (FPN1; SLC40A1), the two isoforms C1 and C2 (p.P570S) of the transferrin protein (TF), the amino acidic substitutions p.H63D and p.C282Y in the hereditary hemochromatosis protein (HFE), and the polymorphism c.-582AG in the promoter of the HEPC gene, which encodes the protein hepcidin (HAMP). Results. The homozygous genotype c.-8GG of the SLC40A1 gene revealed an OR for ISSNHL risk of 4.27 (CI 95%, 2.65-6.89; P = 0.001), being overrepresented among cases. Conclusions. Our study indicates that the homozygous genotype FPN1 -8GG was significantly associated with increased risk of developing sudden hearing loss. These find...Continue Reading

References

Jan 1, 1992·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·A H SunJ Y Li
Jan 1, 1992·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·A H SunL S Kong
Jan 1, 1988·Auris, Nasus, Larynx·Y Yoshimoto
Jul 1, 1985·Acta Oto-laryngologica·J Santos-Sacchi, W F Marovitz
Mar 10, 1997·Journal of the Neurological Sciences·T YamasobaM Sakurai
Oct 26, 1999·Postgraduate Medical Journal·O YossepowitchI S Lossos
Feb 9, 2000·The Journal of Laryngology and Otology·Y H Young, P J Lou
Apr 14, 2000·The Laryngoscope·S D Rauch
Nov 15, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·T NakashimaY Ohno
Jan 28, 2003·Blood Cells, Molecules & Diseases·Xiao-bing LiuDavid J Haile
Jun 18, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Toshihiro SuzukiMasahito Oyamada
Mar 19, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·P CapaccioL Pignataro
May 26, 2005·Brain Research. Brain Research Reviews·Menachem Hanani
May 9, 2006·Free Radical Biology & Medicine·Paolo ZamboniD Gemmati
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philemon S YangDavid T Yue
Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Tomas Ganz
May 4, 2007·Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris·P Tran Ba Huy, E Sauvaget
Jun 2, 2007·Journal of the Association for Research in Otolaryngology : JARO·Irene S GabashviliAnne B S Giersch
Oct 13, 2007·The Journal of Biological Chemistry·Michala Eichner TechauJenefer M Blackwell
Oct 26, 2007·American Journal of Physiology. Renal Physiology·Ruchira Singh, Philine Wangemann
Dec 28, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Zuleyha YildizNejat Akar
Oct 25, 2008·Biochimica Et Biophysica Acta·Sonia Levi, Ermanna Rovida
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Julio SalazarEtienne C Hirsch
Apr 7, 2009·Biochimica Et Biophysica Acta·Michael D Garrick, Laura M Garrick
Apr 24, 2009·BMC Neuroscience·Milla M HänninenSeppo Parkkila
Dec 5, 2009·Journal of Vascular Surgery·Donato GemmatiPaolo Zamboni
Dec 18, 2009·Journal of Cellular and Molecular Medicine·Natascha A WolffCraig P Smith
Feb 16, 2010·Biochemical and Biophysical Research Communications·Ali Shawki, Bryan Mackenzie
Feb 18, 2010·Future Medicinal Chemistry·Eric MillsHaoxing Xu
Jun 1, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Na ZhaoZhimin Du
Jun 16, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·B Blairanne WilliamsAaron B Bowman
Dec 2, 2010·The International Journal of Lower Extremity Wounds·Ajay V SinghPaolo Zamboni
Jan 15, 2011·Journal of Leukocyte Biology·David A WinkCarol A Colton
Mar 26, 2011·Genes & Nutrition·Michael D Garrick
Mar 26, 2011·Journal of Cellular Physiology·Giuseppe ChiarellaEttore Cassandro

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Citations

Nov 30, 2016·International Journal of Immunopathology and Pharmacology·Andrea CiorbaStavros Hatzopoulos
Jul 7, 2020·Vestnik otorinolaringologii·T V ZolotovaA P Davydova
Aug 18, 2020·Ear, Nose, & Throat Journal·Virginia CorazziStavros Hatzopoulos
May 18, 2017·Vestnik otorinolaringologii·S Ya Kosyakov, A I Kirdeeva
Mar 20, 2021·Journal of Proteomics·Rajani G TumaneDhananjay V Raje
Apr 30, 2021·The Journal of Laryngology and Otology·T KuriokaT Yamashita

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PCR

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