Sudden unexpected death in early childhood: general observations in a series of 151 cases: Part 1 of the investigations of the San Diego SUDC Research Project

Forensic Science, Medicine, and Pathology
Marco M HeftiHenry F Krous

Abstract

The purpose of this study was to determine the major subcategories and clinicopathologic features of sudden unexpected death in young children in a large retrospective cohort, and to confirm the association of sudden unexplained death in children (abbreviated by us for unexplained deaths as SUDC) with hippocampal pathology and/or febrile seizures. We undertook analysis of a retrospective cohort of 151 cases, of which 80% (121/151) were subclassified as SUDC, 11% (16/151) as explained, 7% (10/151) as undetermined, and 3% (4/151) as seizure-related. There were no significant differences between SUDC and explained cases in postnatal, gestational, or postconceptional age, frequency of preterm birth, gender, race, or organ weights. In contrast, 96.7% (117/121) of the SUDC group were discovered during a sleep period compared to 53.3% (8/15) of the explained group (p < 0.001), and 48.8% (59/121) of the SUDC cases had a personal and/or family history of febrile seizures compared to 6.7% (1/15) of the explained group (p < 0.001). Of the explained deaths, 56% (9/16) were subclassified as infection, 31% (5/16) cardiac, 6% (1/16) accidental, and 6% (1/16) metabolic. Two of the three cases specifically tested for cardiac channelopathies at ...Continue Reading

References

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Citations

Mar 28, 2016·Forensic Science, Medicine, and Pathology·Michael J AckermanDeborah A Robinson
Mar 30, 2016·Forensic Science, Medicine, and Pathology·Paul A Rutecki, Thomas P Sutula
Mar 30, 2016·Forensic Science, Medicine, and Pathology·Marco M HeftiHenry F Krous
Mar 31, 2016·Forensic Science, Medicine, and Pathology·Colin Smith
Apr 21, 2016·Forensic Science, Medicine, and Pathology·Jeffrey Noebels
Sep 11, 2016·Journal of Neuropathology and Experimental Neurology·Hannah C KinneyRichard D Goldstein
Mar 1, 2017·Pediatric Neurology·Elizabeth J DonnerElaine Wirrell
Apr 27, 2019·JAMA Network Open·Laura Gould CrandallOrrin Devinsky
Aug 12, 2018·Journal of Biomedical Semantics·Ying ShenKai Lei
Jun 22, 2019·Central Nervous System Agents in Medicinal Chemistry·Saganuwan Alhaji Saganuwan
Nov 29, 2017·Frontiers in Cardiovascular Medicine·Manuel RuedaAli Torkamani
Jan 14, 2017·Forensic Science, Medicine, and Pathology·Owen J ArthursNeil J Sebire
Jan 30, 2020·Journal of Neuropathology and Experimental Neurology·Declan McGuoneOrrin Devinsky
Feb 16, 2021·Epilepsia·Jenna HarowitzOrrin Devinsky
Feb 25, 2021·The Application of Clinical Genetics·Christine KeywanIngrid A Holm
Jun 16, 2021·Archives of Disease in Childhood·Shuenn-Nan ChiuMei-Hwan Wu
May 28, 2016·Pediatrics·Richard D GoldsteinMarian Willinger

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