Sudden unexpected death in epilepsy: from mechanisms to prevention

Current Opinion in Neurology
P RyvlinP Kahane

Abstract

To discuss the pathophysiology and potential prevention of sudden unexpected death in epilepsy. Long-term electrocardiogram monitoring over several months has detected ictal asystole in three out of 20 (15%) patients with refractory epilepsy, suggesting that high-risk ictal arrhythmias occur in a greater proportion of patients with refractory epilepsy than previously thought. In case-control studies, sudden unexpected death in epilepsy was found to be associated with frequent generalized tonic-clonic seizures and greater ictal maximal heart rate, especially during nocturnal attacks. Conversely, supervision at night was associated with a lower risk of occurrence. The impact of epilepsy surgery on the risk of death and sudden unexpected death in epilepsy remains unclear, with comparable long-term survival in an epilepsy surgery cohort compared with a matched population of patients with refractory epilepsy who did not undergo surgery. Previous results may have been partly confounded by the association observed between preoperative decreased heart rate variability and poor postoperative seizure outcome. Ictal arrhythmias may represent a more prevalent cause of sudden unexpected death in epilepsy than previously thought. No clear re...Continue Reading

References

Feb 1, 1984·Archives of Neurology·D L Coulter
May 1, 1981·Annals of Neurology·C F TerrenceJ A Perper
Apr 1, 1995·Annals of Neurology·S C JohnstonR P Simon
Sep 1, 1993·Epilepsia·B SinghS M al Deeb
Mar 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·L NashefD R Fish
Mar 1, 1996·Seizure : the Journal of the British Epilepsy Association·S J TavernorC Gifford
May 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·U SpechtP Wolf
Oct 24, 1997·Annals of Neurology·S C JohnstonK D Laxer
Jun 17, 1998·Archives of Neurology·B H NatelsonR Turizo
Jul 13, 1999·Annals of Neurology·M R SperlingM J O'Connor
Sep 16, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R Kloster, T Engelskjøn
Jan 25, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·Y LanganJ W Sander
Jun 10, 2000·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·K OpeskinS F Berkovic
Aug 10, 2000·American Journal of Mental Retardation : AJMR·J R McKee, J W Bodfish
Dec 15, 2000·Archives of Neurology·R T Cheung, V Hachinski
Feb 27, 2001·Neurology·J A RacoosinG Boehm
Jan 11, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·H AnsakorpiJ I T Isojärvi
May 25, 2002·Journal of Sleep Research·Raffaele FerriMariangela Tripodi
Jun 5, 2002·Lancet·Timothy A Pedley, W Allen Hauser
Nov 30, 2002·Epilepsy Research·Christian OpherkLawrence J Hirsch
Dec 5, 2002·The American Journal of Forensic Medicine and Pathology·Lisa B E ShieldsJoseph C Parker
Feb 13, 2003·Neurology·David J StraussYvonne W Wu
Apr 19, 2003·Epilepsia·Lena NilssonTorbjōrn Tomson
May 29, 2003·Neurology·B K WoodruffA S Jaffe
Jul 3, 2003·Epilepsy Research·Megdad M ZaatrehBradley B Vaughn
Jul 16, 2003·Epilepsia·Philippe Ryvlin
Jul 17, 2003·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·M SeeckE Roulet
Sep 12, 2003·Seizure : the Journal of the British Epilepsy Association·Kenneth Opeskin, Samuel F Berkovic
Nov 11, 2003·Journal of the Neurological Sciences·Max J HilzAchim Druschky
Dec 4, 2003·Epilepsy Research·P Ryvlin, P Kahane
Mar 20, 2004·Epilepsia·Maromi NeiMichael R Sperling
May 12, 2004·Epilepsy Research·Claudia Stöllberger, Josef Finsterer
Jul 24, 2004·Epilepsia·Hanna AnsakorpiJouko I T Isojärvi

❮ Previous
Next ❯

Citations

Sep 28, 2013·JAAPA : Official Journal of the American Academy of Physician Assistants·Douglas S Larsen, Azeemuddin Ahmed
Aug 29, 2009·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ali A Asadi-Pooya, Michael R Sperling
Jan 14, 2010·Epilepsia·Cristian Sevcencu, Johannes J Struijk
Jan 19, 2011·Epilepsia·George B Richerson, Gordon F Buchanan
Jul 18, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Hannah C KinneyHenry F Krous
Dec 19, 2013·Epilepsy Currents·George B Richerson
Apr 19, 2008·Neuro-Chirurgie·P Ryvlin, A Montavont
Nov 28, 2008·Neuroscience Bulletin·Ricardo M AridaFulvio A Scorza
Jan 28, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Dag AurlienKarl O Nakken
Sep 14, 2010·Journal of the Neurological Sciences·Fulvio A ScorzaRicardo M Arida
May 11, 2010·Epilepsy & Behavior : E&B·Fulvio A ScorzaEsper A Cavalheiro
Feb 9, 2010·Journal of Ethnopharmacology·Muhammad Liaquat RazaShabana U Simjee
Nov 26, 2009·Medical Hypotheses·Fulvio A ScorzaEsper A Cavalheiro
Feb 11, 2015·Epilepsy & Behavior Case Reports·Giada Giovannini, Stefano Meletti
Jan 28, 2009·La Presse médicale·Philippe RyvlinAlexandra Montavont
Apr 4, 2009·Epilepsy & Behavior : E&B·Margaret P JacobsJohn W Swann
Jan 27, 2009·Epilepsy & Behavior : E&B·Lineu CalderazzoFulvio A Scorza
Jan 10, 2009·Epilepsy & Behavior : E&B·John R Hughes
Dec 27, 2008·Epilepsy & Behavior : E&B·Vera C Terra-BustamanteFulvio A Scorza
Sep 23, 2008·Lancet Neurology·Torbjörn TomsonPhilippe Ryvlin
Mar 4, 2008·Epilepsy Research·Olgu HalliogluKhatuna Makharoblidze
Dec 7, 2007·Medical Hypotheses·Diego B ColugnatiFulvio A Scorza
Mar 19, 2014·Seizure : the Journal of the British Epilepsy Association·Ebru KolsalEbru Arhan
Dec 1, 2011·Pacing and Clinical Electrophysiology : PACE·Poonam VelagapudiAbraham Kocheril
May 10, 2013·Epilepsia·Philippe RyvlinTorbjörn Tomson
Sep 9, 2009·Archives of Physical Medicine and Rehabilitation·Cynthia L Harrison-FelixDenise M Hart
Aug 23, 2012·Seizure : the Journal of the British Epilepsy Association·Denis D DamascenoAlvair P Almeida
Aug 18, 2012·Seizure : the Journal of the British Epilepsy Association·A MeghanaP Satishchandra
May 12, 2007·Seizure : the Journal of the British Epilepsy Association·Håkan PerssonT Tomson
Feb 14, 2013·Epilepsy & Behavior : E&B·Vera C TerraFulvio A Scorza
Aug 23, 2012·Epilepsy & Behavior : E&B·Fulvio A Scorza, Josemir W Sander
Jun 9, 2012·Epilepsy & Behavior : E&B·Carla Delascio LopesFulvio Alexandre Scorza
Aug 24, 2010·Brazilian Journal of Biology = Revista Brasleira De Biologia·F A ScorzaE A Cavalheiro
Jan 14, 2010·Arquivos de neuro-psiquiatria·Carla A ScorzaiFulvio A Scorza
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Fulvio A ScorzaEsper A Cavalheiro
Aug 24, 2010·Arquivos de neuro-psiquiatria·Diego B ColugnatiFulvio A Scorza
Jul 23, 2009·Arquivos de neuro-psiquiatria·Marly de AlbuquerqueFulvio A Scorza
Aug 31, 2011·Arquivos de neuro-psiquiatria·Fulvio A ScorzaRonald M Harper
Jul 20, 2016·The Cochrane Database of Systematic Reviews·Melissa J MaguireSarah J Nolan
Jun 7, 2018·Epilepsia·Philippe RyvlinSandor Beniczky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.