Sudden unexpected death in epilepsy, periictal physiology, and the SUDEP-7 Inventory

Epilepsia
Nicole Odom, Lisa M Bateman

Abstract

Sudden unexpected death in epilepsy (SUDEP) is a significant public health burden. Epidemiological studies have identified clinical SUDEP risk factors across large populations, but the means to apply this information to individual patients are lacking. The SUDEP-7 Inventory was developed as a marker of clinical SUDEP risk and has been used in studies of potential SUDEP biomarkers. We retrospectively reviewed clinical data from 16 patients dying of SUDEP and 48 matched living epilepsy controls to determine whether individuals succumbing to SUDEP could be distinguished from living epilepsy controls using the revised SUDEP-7 Inventory, the absolute number of clinical risk factors as identified by an International League Against Epilepsy meta-analysis (ILAE score), and physiological characteristics previously associated with SUDEP risk. Mean revised SUDEP-7 Inventory score was 3.3 ± 2.0 in SUDEP cases and 3.8 ± 2.3 in controls (P = 0.39). Mean ILAE score was 2.4 ± 1.1 in SUDEP cases and 2.6 ± 1.4 in controls (P = 0.62). There were no significant differences in interictal heart rate variability (measured by the root mean square of differences of successive RR intervals), periictal cardiorespiratory dysfunction, and postictal general...Continue Reading

References

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Jun 16, 2011·Epilepsia·Dale C HesdorfferUNKNOWN ILAE Commission on Epidemiology; Subcommission on Mortality
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Citations

Jan 30, 2019·Current Opinion in Neurology·Philippe RyvlinSamden D Lhatoo
Jan 26, 2021·Epilepsy & Behavior : E&B·Aileen McGonigalEric Guedj
Nov 3, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·L Brian HickmanBen Julian A Palanca
Feb 29, 2020·Seizure : the Journal of the British Epilepsy Association·Katharina MahrAdam Strzelczyk
Apr 11, 2021·Neurology·William SzurhajJulien De Jonckheere
Apr 30, 2021·Neurology·Ashwani JhaOrrin Devinsky
May 29, 2021·Annals of Clinical and Translational Neurology·Giorgio CostagliolaPasquale Striano
Jun 5, 2021·Epilepsia·Roozbeh Tarighati RasekhiMaromi Nei
Aug 24, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Emily Wicker, Justin W Cole
Sep 22, 2021·Epilepsia·Roozbeh Tarighati RasekhiMaromi Nei
Oct 16, 2021·Neurology·Roland D Thijs, Josemir W Sander
Oct 16, 2021·Neurology·Shobi SivathambooUNKNOWN MS-BioS Study Group

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