Sudden unexplained nocturnal death syndrome in Southern China: an epidemiological survey and SCN5A gene screening.

The American Journal of Forensic Medicine and Pathology
Jianding ChengStacie Kroboth

Abstract

Based on autopsy data collected in Southern China from 2001-2006, 975 cases of sudden unexplained nocturnal death syndrome (SUNDS) were surveyed. Genetic screening of SCN5A gene encoding the voltage dependent cardiac sodium channel was performed in 74 SUNDS cases. The annual occurrence rate of SUNDS in the area was estimated to be about 1 per 100,000 people. About 80.6% of deaths occurred between the ages of 21 to 40 years and the case number peaked at age 30 years. In 75.4% of cases with witnesses, victims died asleep between 11 PM and 4 AM and they showed predominantly abrupt respiratory distress shortly preceding death. The monthly distribution of emergency fever cases in the area during the same period was positively correlated to that of SUNDS cases (r(s) = 0.611, P = 0.035). Four polymorphisms in SCN5A were identified in both SUNDS and control groups. Compared with controls, the allele frequency of C5457 and C3666 + 69 were significant higher in SUNDS (P < 0.005) while the genotypes of both 5457CC (P = 0.012, OR = 2.0, 95% CI = 1.3-3.2) and 3666+69CC (P = 0.004, OR = 2.1, 95% CI = 1.3-3.3) in SUNDS cases were significantly higher. This is the first report of an epidemiological survey and SCN5A gene screening in SUNDS in t...Continue Reading

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Citations

Feb 18, 2014·Forensic Science International : Synergy·Chao LiuJianding Cheng
Jan 10, 2013·Current Oncology·S Ahmed, R K Shahid
Apr 25, 2012·The Canadian Journal of Hospital Pharmacy·Jean Lachaine, Catherine Beauchemin
Jul 12, 2012·The Canadian Journal of Hospital Pharmacy·Duane BatesJennifer M Bugar
Aug 25, 2012·The Canadian Journal of Hospital Pharmacy·Lalitha Raman-Wilms
Aug 25, 2012·The Canadian Journal of Hospital Pharmacy·Kevin HallJames E Tisdale
Dec 20, 2016·Forensic Science International : Synergy·Qiuping WuJianding Cheng
Mar 5, 2018·Journal of the American Heart Association·Jingjing ZhengJianding Cheng
Jan 27, 2015·The American Journal of Forensic Medicine and Pathology·Jinxiang ZhengJianding Cheng
Nov 7, 2012·Current Opinion in Cardiology·Hariharan Raju, Elijah R Behr

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