Sugammadex at both high and low doses does not affect the depth of anesthesia or hemodynamics: a randomized double blind trial

Journal of Clinical Monitoring and Computing
Argyro FassoulakiChryssoula Staikou

Abstract

Previous studies have shown that sugammadex decreases the anesthetic depth when administered to reverse the neuromuscular blockade produced by rocuronium/vecuronium. The aim of the present study was to investigate the effect of sugammadex alone on anesthetic depth and hemodynamics. Sixty patients scheduled for abdominal surgery participated in the study. Anesthesia was induced with thiopental/fentanyl and maintained with N2O/oxygen and sevoflurane concentrations adjusted to maintain Entropy and Bispectral Index (BIS) values between 40 and 50. Cis-atracurium 0.2 mg/kg was administered for neuromuscular blockade which was monitored with a TOF-Watch(®) SX acceleromyograph. State entropy (SE), response entropy (RE), Bispectral Index (BIS), systolic (SAP) and diastolic blood pressure (DAP), heart rate (HR), SpO2, end-tidal CO2 and sevoflurane concentrations were recorded every 3 min intraoperatively. Sugammadex 2 mg/kg (Group-2), 4 mg/kg (Group-4) or 16 mg/kg (Group-16) was given intravenously when a count of two responses of the train-of-four (TOF) or a post-tetanic count (PTC) 1-3 appeared or when no response at all (PTC = 0) was observed, respectively. The overall SE values, thus the primary outcome of the study, were 44 ± 11, 43...Continue Reading

References

Feb 28, 2002·Anesthesia and Analgesia·Robert GreifDaniel I Sessler
Mar 22, 2005·British Journal of Anaesthesia·F C VasellaL Magnusson
Aug 25, 2010·Journal of Clinical Monitoring and Computing·Hanna IllmanKlaus T Olkkola
Jan 1, 2010·Sensors·Bojan Musizza, Samo Ribaric

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