Sugar and artificially sweetened beverages and risk of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality: a dose-response meta-analysis of prospective cohort studies

European Journal of Epidemiology
Pei QinMing Zhang

Abstract

Although consumption of sugar-sweetened beverages (SSBs) and artificially sweetened beverages (ASBs) has increasingly been linked with obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality, evidence remains conflicted and dose-response meta-analyses of the associations are lacking. We conducted an updated meta-analysis to synthesize the knowledge about their associations and to explore their dose-response relations. We comprehensively searched PubMed, EMBASE, Web of Science, and Open Grey up to September 2019 for prospective cohort studies investigating the associations in adults. Summary relative risks (RRs) and 95% confidence intervals (CIs) were estimated for the dose-response association. Restricted cubic splines were used to evaluate linear/non-linear relations. We included 39 articles in the meta-analysis. For each 250-mL/d increase in SSB and ASB intake, the risk increased by 12% (RR = 1.12, 95% CI 1.05-1.19, I2 = 67.7%) and 21% (RR = 1.21, 95% CI 1.09-1.35, I2 = 47.2%) for obesity, 19% (RR = 1.19, 95% CI 1.13-1.25, I2 = 82.4%) and 15% (RR = 1.15, 95% CI 1.05-1.26, I2 = 92.6%) for T2DM, 10% (RR = 1.10, 95% CI 1.06-1.14, I2 = 58.4%) and 8% (RR = 1.08, 95% CI 1.06-1.10, I2 = 24.3%) for hypertension, and ...Continue Reading

References

Jun 1, 1992·American Journal of Epidemiology·S Greenland, M P Longnecker
Jun 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Hallfrisch
Oct 26, 2002·The American Journal of Clinical Nutrition·Sharon S ElliottPeter J Havel
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Aug 26, 2004·JAMA : the Journal of the American Medical Association·Matthias B SchulzeFrank B Hu
Feb 6, 2007·Preventive Medicine·Annlia Paganini-HillMaría M Corrada
Dec 12, 2007·Obesity·Kiyah J Duffey, Barry M Popkin
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Carole WilliJacques Cornuz
Jul 30, 2008·Archives of Internal Medicine·Julie R PalmerLynn Rosenberg
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Dec 10, 2009·JAMA : the Journal of the American Medical Association·David S Ludwig
Feb 8, 2011·European Journal of Epidemiology·Akiko TamakoshiUNKNOWN JACC Study Group
Mar 25, 2011·The American Journal of Clinical Nutrition·Lawrence de KoningFrank B Hu
Jul 15, 2011·The American Journal of Clinical Nutrition·Jean A WelshMiriam B Vos
Jan 10, 2012·The Journal of Nutrition·Sohyun ParkTerrence O'Toole
Apr 28, 2012·Journal of General Internal Medicine·Lisa CohenJohn Forman
May 16, 2012·Physiology & Behavior·Erin Green, Claire Murphy
Aug 25, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ehab S EshakShoichiro Tsugane
Nov 16, 2012·The American Journal of Clinical Nutrition·Shilpa N BhupathirajuFrank B Hu
Sep 26, 2013·Diabetes·Richard J JohnsonMiguel A Lanaspa
Feb 21, 2014·The American Journal of Clinical Nutrition·Natasha TasevskaNancy Potischman
Apr 20, 2014·The Journal of Nutrition·Dalia SternBarry M Popkin
Jul 18, 2014·The American Journal of Clinical Nutrition·Adam Drewnowski, Colin D Rehm
Dec 8, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Carmen Sayon-OreaMaira Bes-Rastrollo
Jan 15, 2015·Preventive Medicine·Sara N Bleich, Julia A Wolfson
Mar 4, 2015·The Journal of Nutrition·Andrew O OdegaardMark A Pereira
Mar 5, 2015·The British Journal of Nutrition·Bo XiDonghao Zhou
May 15, 2015·Journal of Diabetes Investigation·Meng WangRu-Ying Hu
Jun 27, 2015·Clinical and Experimental Hypertension : CHE·Wisit CheungpasitpornStephen B Erickson
Aug 6, 2015·PloS One·Gitanjali M SinghUNKNOWN Global Burden of Diseases Nutrition and Chronic Diseases Expert Group (NutriCoDE)

❮ Previous
Next ❯

Citations

Jun 12, 2021·The Journal of Nutrition·Andrea Romanos-NanclaresA Heather Eliassen
Aug 20, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Tim Lobstein, Kelly D Brownell
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Maria G Tinajero, Vasanti S Malik

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.