Sugar-Breathing Glycopolymersomes for Regulating Glucose Level

Journal of the American Chemical Society
Yufen XiaoJianzhong Du

Abstract

Diabetes mellitus is a chronic, life-threatening illness that affects people of every age and ethnicity. It is a long-term pain for those who are affected and must regulate their blood glucose level by frequent subcutaneous injection of insulin every day. Herein, we propose a noninsulin and antidiabetic drug-free strategy for regulating blood glucose level by a nanosized "sugar sponge" which is a lectin-bound glycopolymersome capable of regulating glucose due to the dynamic recognition between the lectin and different carbohydrates. The glycopolymersome is self-assembled from poly(ethylene oxide)-block-poly[(7-(2-methacryloyloxyethoxy)-4-methylcoumarin)-stat-2-(diethylamino)ethyl methacrylate-stat-(α-d-glucopyranosyl)ethyl methacrylate] [PEO-b-P(CMA-stat-DEA-stat-GEMA)]. The lectin bound in the glycopolymersome has different affinity for the glucose in the blood and the glucosyl group in the glycopolymersome. Therefore, this sugar sponge functions as a glucose storage unit by dynamic sugar replacement: The lectin in the sugar sponge will bind and store the glucose from its surrounding solution when the glucose concentration is too high and will release the glucose when the glucose concentration is too low. In vitro, this sugar-...Continue Reading

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Citations

Sep 11, 2018·Nanoscale·Hui Sun, Jianzhong Du
May 22, 2019·Macromolecular Rapid Communications·Jidong TanYanfeng Zhang
Aug 20, 2019·Advanced Materials·Jinqiang WangZhen Gu
Dec 24, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yufen Xiao, Jianzhong Du
May 13, 2020·Physical Chemistry Chemical Physics : PCCP·Claire E MeyerCornelia G Palivan
Aug 12, 2020·Biomaterials Science·Xingyu Chen, Dongqiong Yang
Oct 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuanxiu HongJianzhong Du
Jan 27, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liyun XingYuan Huang
Feb 2, 2021·ACS Biomaterials Science & Engineering·Jie WangJian Dong
Mar 17, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ping WeiJianzhong Du
Apr 2, 2021·Journal of Colloid and Interface Science·Laurent LatxaguePhilippe Barthélémy
Aug 4, 2021·Journal of Colloid and Interface Science·Yun FuWeiping Zhu
Aug 17, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Jing QuanHua Wu
Jul 28, 2018·Nano Letters·Fangyingkai WangJianzhong Du
Sep 14, 2018·Journal of the American Chemical Society·Yan SunPeter J Stang
Mar 10, 2020·Journal of the American Chemical Society·Jiangang Xiao, Jianzhong Du
Jan 19, 2021·ACS Biomaterials Science & Engineering·Hongping LiPeihong Ni
Aug 22, 2021·Macromolecular Rapid Communications·Junpeng CaoJianbo Tan
Aug 15, 2021·Angewandte Chemie·Yi ZhengMingming Ding
Sep 17, 2021·Nano Letters·Xue ZhouJianzhong Du
Nov 27, 2021·Advanced Science·Yuntao LiuGuoqing Pan

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