Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds.

Journal of Burn Care & Research : Official Publication of the American Burn Association
Jennifer K Plichta, Katherine A Radek

Abstract

Thousands of patients suffer from burn injuries each year, yet few therapies have been developed to accelerate the wound healing process. Most fibroblast growth factors (FGFs) have been extensively evaluated but only a few have been found to participate in the wound healing process. In particular, FGF-10 is robustly increased in the wound microenvironment after injury and has demonstrated some ability to promote wound healing in vitro and in vivo. Glycosaminoglycans are linear carbohydrates that participate in wound repair by influencing cytokine/growth factor localization and interaction with cognate receptors. Dermatan sulfate (DS) is the most abundant glycosaminoglycan in human wound fluid and has been postulated to be directly involved in the healing process. Recently, the combination of FGF-10 and DS demonstrated the potential to accelerate wound healing via increased keratinocyte proliferation and migration. Based on these preliminary studies, DS may serve as a cofactor for FGF-10, and together they are likely to expedite the healing process by stimulating keratinocyte activity. As a specific subtype of wounds, the overall healing process of burn injuries does not significantly differ from other types of wounds, where opt...Continue Reading

References

Jul 1, 1991·Trends in Biochemical Sciences·I VlodavskyZ Fuks
Sep 1, 1986·Journal of Cellular Physiology·D Gospodarowicz, J Cheng
Feb 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O OksalaH Larjava
Apr 1, 1994·Archives of Dermatology·G S LazarusM C Robson
Sep 1, 1995·Journal of Cellular Biochemistry·C T BrownV Trinkaus-Randall
Feb 10, 1997·The Journal of Cell Biology·K G DanielsonR V Iozzo
Sep 12, 1997·The Journal of Biological Chemistry·H EmotoN Itoh
Oct 17, 1998·The Journal of Biological Chemistry·S F PencR L Gallo
Jan 23, 1999·Nature Genetics·K SekineS Kato
Feb 3, 1999·The Journal of Surgical Research·P A Jimenez, M A Rampy
Mar 31, 1999·Diabetes Care·S D RamseyE H Wagner
Jul 27, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·P M SolerM C Robson
Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D M Ornitz
Feb 8, 2000·The Journal of Burn Care & Rehabilitation·P D SmithC M Robson
Mar 15, 2000·The International Journal of Biochemistry & Cell Biology·S TumovaJ R Couchman
Oct 6, 2000·Endocrine-related Cancer·C J PowersA Wellstein
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D S HanR B Sartor
Nov 4, 2000·Biochemical and Biophysical Research Communications·H OhuchiN Itoh
Apr 5, 2001·The Journal of Investigative Dermatology·C MarcheseM R Torrisi
Oct 27, 2001·Clinical and Experimental Dermatology·E A O'Toole
Mar 19, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·M C RobsonD L Steed
Apr 27, 2002·Science·Julie JamesonWendy L Havran
Sep 6, 2002·Glycobiology·Janet M Trowbridge, Richard L Gallo
Sep 7, 2002·The Journal of Biological Chemistry·Janet M TrowbridgeRichard L Gallo
Mar 5, 2003·Biochemical and Biophysical Research Communications·Hideyo OhuchiKatsuhiko Ono
Sep 19, 2003·Pathophysiology of Haemostasis and Thrombosis·Giuseppe G Nenci
Jul 22, 2004·The Cochrane Database of Systematic Reviews·E VillanuevaJ P Lehm
Aug 31, 2004·Diabetes Care·Karen StocklEunice Chang
Nov 26, 2004·The Journal of Biological Chemistry·Kristen R TaylorRichard L Gallo
Jan 18, 2005·World Journal of Surgery·Bishara S AtiyehShady N Hayek
Mar 31, 2005·Chemistry & Biology·Rahul RamanRam Sasisekharan
May 3, 2005·Cytokine & Growth Factor Reviews·V P EswarakumarJ Schlessinger

❮ Previous
Next ❯

Citations

Jan 7, 2014·Drug Design, Development and Therapy·Sergio Coccheri, Ferdinando Mannello
Feb 6, 2016·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Alena KobesovaRoss Andel
Feb 28, 2013·The FEBS Journal·Martin A ThelinAnders Malmstrom
Sep 5, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Renata GustafssonAke Oldberg
Mar 3, 2015·Journal of Tissue Engineering and Regenerative Medicine·A Herrero-MendezA Alonso-Varona
Jul 30, 2015·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Olivia NumminenRiitta Meretoja
Mar 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Pawel OlczykEwa M Kozma
Sep 30, 2016·Journal of Wound, Ostomy, and Continence Nursing : Official Publication of the Wound, Ostomy and Continence Nurses Society·Alma AkhmetovaSergey Mikhalovsky
Sep 20, 2015·Protein Expression and Purification·Jian HuangChao Jiang
Feb 10, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Miguel ConchaSandra L Orellana
Mar 3, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Sylvia GruberWolfgang Dörr
Dec 18, 2015·PloS One·Hieu T NimSarah E Boyd
Jun 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoming SunWenguo Cui
Mar 28, 2019·Revista brasileira de enfermagem·Magali Rezende de CarvalhoBeatriz Guitton Renaud Baptista de Oliveira
Nov 16, 2018·Frontiers in Genetics·Lawrence S Prince
May 8, 2019·Stem Cells and Development·Jenny WigénGunilla Westergren-Thorsson
Aug 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vitor H PominBarbara Mulloy
Dec 13, 2019·Advances in Wound Care·Thomas Charles LangChristopher John Jackson
Oct 9, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fakiha SiddiquiJawed Fareed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.