Sugar-conjugated dendritic mesoporous silica nanoparticles as pH-responsive nanocarriers for tumor targeting and controlled release of deferasirox

Materials Science & Engineering. C, Materials for Biological Applications
Arezoo Sodagar TaleghaniAzim Akbarzadeh

Abstract

In this work, a new pH-responsive nanocarrier based on mesoporous silica nanoparticle which was functionalized by polyamidoamine dendrimer with sugar conjugation was designed for targetable and controllable delivery of deferasirox to cancer cells. To obtain the optimum conditions for the preparation of drug-loaded nanocarrier, the response surface method was employed. The effect of drug/silica ratio, temperature, and operation time on loading efficiency of deferasirox was evaluated, and high loading content achieved under optimized condition. The in vitro drug release studies at different pHs proved the pH-sensitivity of the nanocarrier. Due to the open state of dendritic structure in acidic pH, the maximum release observed at pH 4.5 (lysosomal pH). In the presence of the sugar decorated carrier, cytotoxicity of retinoblastoma cell line Y79 was enhanced which confirmed that tumor cell uptake was improved. These results suggested that this nanocarrier has the potential for treatment of cancer.

Citations

Oct 1, 2020·Journal of Drug Targeting·Zaynab Sadeghi-GhadiAli Nokhodchi
Jun 2, 2020·Biotechnology Journal·Jorge Parra-NietoAlejandro Baeza
May 14, 2020·Nanomaterials·Miguel Gisbert-Garzarán, María Vallet-Regí
May 21, 2019·Journal of Microencapsulation·Zaynab Sadeghi Ghadi, Pedram Ebrahimnejad
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajesh SalveWassana Yantasee
Apr 11, 2021·Tropical Medicine & International Health : TM & IH·Pedram EbrahimnejadAhmadali Enayati

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