Sugar-Grafted Cyclodextrin Nanocarrier as a "Trojan Horse" for Potentiating Antibiotic Activity

Pharmaceutical Research
Min LiLi Yang Hsu

Abstract

The use of "Trojan Horse" nanocarriers for antibiotics to enhance the activity of antibiotics against susceptible and resistant bacteria is investigated. Antibiotic carriers (CD-MAN and CD-GLU) are prepared from β-cyclodextrin grafted with sugar molecules (D-mannose and D-glucose, respectively) via azide-alkyne click reaction. The sugar molecules serve as a chemoattractant enticing the bacteria to take in higher amounts of the antibiotic, resulting in rapid killing of the bacteria. Three types of hydrophobic antibiotics, erythromycin, rifampicin and ciprofloxacin, are used as model drugs and loaded into the carriers. The minimum inhibitory concentration of the antibiotics in the CD-MAN-antibiotic and CD-GLU-antibiotic complexes for Gram-negative Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii strains, and a number of Gram-positive Staphylococcus aureus strains, including the methicillin-resistant strains (MRSA), are reduced by a factor ranging from 3 to >100. The CD-MAN-antibiotic complex is also able to prolong the stability of the loaded antibiotic and inhibit development of intrinsic antibiotic resistance in the bacteria. These non-cytotoxic sugar-modfied nanocarriers can potentiate the activity of exist...Continue Reading

References

Oct 1, 1996·Journal of Pharmaceutical Sciences·T Loftsson, M E Brewster
Aug 24, 1999·The Journal of Biological Chemistry·M PajatschH Engelhardt
Jun 23, 2001·The Journal of Antimicrobial Chemotherapy·J M Andrews
Jun 23, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Axel FetznerRolf Schubert
Mar 16, 2007·Public Health Reports·R Monina KlevensDenise M Cardo
Feb 9, 2008·Emerging Infectious Diseases·Eili KleinRamanan Laxminarayan
Mar 27, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gregory S Schultz, Annette Wysocki
Jun 6, 2009·FEMS Microbiology Letters·Mohamed N SeleemNammalwar Sriranganathan
Jun 29, 2011·FEMS Microbiology Reviews·Dan I Andersson, Diarmaid Hughes
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Zhigang QiuJun-Wen Li
Sep 25, 2012·Cellular & Molecular Biology Letters·Elżbieta PiątkowskaAnna Przondo-Mordarska
Mar 8, 2013·The Journal of Antimicrobial Chemotherapy·G E RichmondL J V Piddock
Apr 20, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W BoucherUNKNOWN Infectious Diseases Society of America
Jul 31, 2013·Advanced Drug Delivery Reviews·Robert Y Pelgrift, Adam J Friedman
Dec 5, 2013·Expert Opinion on Drug Delivery·Sai V ChilajwarVilasrao J Kadam
Jan 31, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V G Fowler, R A Proctor
Apr 25, 2014·Journal of Nanoscience and Nanotechnology·Rajni SinghSurinder P Singh
Jul 6, 2014·Chemical Society Reviews·Wen Tang, Matthew L Becker
Dec 3, 2014·Trends in Pharmacological Sciences·Eric Oldfield, Xinxin Feng
Feb 6, 2015·Microbiology and Molecular Biology Reviews : MMBR·Hsiao-Han ChangMarc Lipsitch
Feb 11, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·John F QuinnThomas P Davis

❮ Previous
Next ❯

Citations

Aug 9, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daham JeongSeunho Jung
Mar 9, 2019·Expert Opinion on Drug Delivery·Saeideh AllahyariParvin Zakeri-Milani
May 18, 2019·Biomaterials Science·Min LiKoon Gee Neoh
Jul 18, 2019·Organic & Biomolecular Chemistry·Urjwan AlaliVéronique Bonnet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
B J DennyJ Zamocka
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Matthew E FalagasArgyris Michalopoulos
Nihon rinsho. Japanese journal of clinical medicine
Yoshinori Yamano
Recent Patents on Anti-infective Drug Discovery
Tze S LoEileen A R Vicaldo-Alonto
© 2022 Meta ULC. All rights reserved