Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis.

Diabetologia
Nicola M McKeownMark A Herman

Abstract

Sugar-sweetened beverages (SSBs) are a major dietary contributor to fructose intake. A molecular pathway involving the carbohydrate responsive element-binding protein (ChREBP) and the metabolic hormone fibroblast growth factor 21 (FGF21) may influence sugar metabolism and, thereby, contribute to fructose-induced metabolic disease. We hypothesise that common variants in 11 genes involved in fructose metabolism and the ChREBP-FGF21 pathway may interact with SSB intake to exacerbate positive associations between higher SSB intake and glycaemic traits. Data from 11 cohorts (six discovery and five replication) in the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided association and interaction results from 34,748 adults of European descent. SSB intake (soft drinks, fruit punches, lemonades or other fruit drinks) was derived from food-frequency questionnaires and food diaries. In fixed-effects meta-analyses, we quantified: (1) the associations between SSBs and glycaemic traits (fasting glucose and fasting insulin); and (2) the interactions between SSBs and 18 independent SNPs related to the ChREBP-FGF21 pathway. In our combined meta-analyses of discovery and replication cohorts, after adjustmen...Continue Reading

References

Jun 1, 1996·Pflügers Archiv : European journal of physiology·C P CorpeG L Kellett
Jun 5, 1999·The American Journal of Cardiology·S M Grundy
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katsumi IizukaKosaku Uyeda
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yasushi OgawaMakoto Kuro-o
Jan 15, 2008·Nature Genetics·Jaspal S KoonerJohn F Thompson
Jul 25, 2008·The Biochemical Journal·Loranne Agius
Aug 8, 2009·FEBS Letters·Katsumi IizukaYukio Horikawa
Oct 6, 2009·Biochemical and Biophysical Research Communications·Hyun-Young KooManabu T Nakamura
Dec 24, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Donald B Jump
Sep 25, 2012·The New England Journal of Medicine·Qibin QiLu Qi
Dec 5, 2012·PloS One·Andrew C AdamsAlexei Kharitonenkov
Feb 2, 2013·Human Molecular Genetics·Audrey Y ChuUNKNOWN DietGen Consortium
May 2, 2013·European Journal of Clinical Nutrition·S Bel-SerratUNKNOWN IDEFICS consortium
May 3, 2013·The American Journal of Clinical Nutrition·Toshiko TanakaJennifer A Nettleton
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Jan 7, 2014·Journal of Molecular Endocrinology·Yuumi IshizukaUNKNOWN Jichi Medical University Promotion Team of Large-Scale Human Genome Bank for All over Japan
Jan 10, 2014·The Journal of Clinical Investigation·Brice EmanuelliC Ronald Kahn
Apr 9, 2014·Trends in Endocrinology and Metabolism : TEM·Ruth E Gimeno, David E Moller
Feb 17, 2015·Molecular Metabolism·Jody R DushayEleftheria Maratos-Flier
May 15, 2015·Journal of Diabetes Investigation·Meng WangRu-Ying Hu
Jan 5, 2016·Cell Metabolism·Saswata TalukdarSteven A Kliewer

❮ Previous
Next ❯

Citations

Nov 19, 2019·Frontiers in Genetics·Ruixue HouV Saroja Voruganti
Aug 9, 2020·Health Economics·Brandon J Restrepo, Jonathan H Cantor
Oct 8, 2021·Cell Metabolism·Mark A Herman, Morris J Birnbaum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.