Suggested modification of presentation of stroke trial results

International Journal of Stroke : Official Journal of the International Stroke Society
M GoyalM D Hill

Abstract

The modified Rankin Scale (mRS) at 90 days after stroke onset has become the preferred outcome measure in acute stroke trials, including recent trials of interventional therapies. Reporting the range of modified Rankin Scale scores as a paired horizontal stacked bar graph (colloquially known as "Grotta bars") has become the conventional method of visualizing modified Rankin Scale results. Grotta bars readily illustrate the levels of the ordinal modified Rankin Scale in which benefit may have occurred. However, complementing the available graphical information by including additional features to convey statistical significance may be advantageous. We propose a modification of the horizontal stacked bar graph with illustrative examples. In this suggested modification, the line joining the segments of the bar graph (e.g. modified Rankin Scale 1-2 in treatment arm to modified Rankin Scale 1-2 in control arm) is given a color and thickness based on the p-value of the result at that level (in this example, the p-value of modified Rankin Scale 0-1 vs. 2-6)-a thick green line for p-values <0.01, thin green for p-values of 0.01 to <0.05, gray for 0.05 to <0.10, thin red for 0.10 to <0.90, and thick red for p-values ≥0.90 or outcome favo...Continue Reading

References

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Citations

Jul 6, 2019·Stroke; a Journal of Cerebral Circulation·Mohammed A AlmekhlafiMayank Goyal

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Software Mentioned

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