Suggestion of a deficient osteoblastic function in diabetes mellitus: the possible cause of osteopenia in diabetics

Calcified Tissue International
H RicoF Gomez-Castresana

Abstract

The mechanism underlying diabetic osteopenia is still unclear and may involve osteoblastic activity and/or the deficit of insulin's anabolic action. Bone gla protein (BGP) is synthesized by the osteoblast and its synthesis increases with 1,25(OH)2D3 and fluoride. Because 1,25(OH)2D3 also stimulates insulin secretion, sodium fluoride administration can be used to investigate deficient osteoblastic activity in diabetics, as reflected by BGP levels. BGP was determined before and after administering sodium fluoride at a dosage of 50 mg/day/15 days to three groups: 14 patients with insulin-dependent diabetes, 16 diabetics on oral antidiabetic treatment, and 25 controls, all of similar age, sex, and characteristics. Basal BGP values (mean +/- SD) were low in diabetics on insulin treatment (4.3 +/- 1.1 ng/ml) and in diabetics on oral antidiabetics (5.8 +/- 1.2 ng/ml) as compared with controls (6.5 +/- 0.7 ng/ml) (P less than 0.001 and less than 0.05, respectively). After giving fluoride, BGP values did not change in the two diabetic groups but did vary in controls (8.1 +/- 0.6 ng/ml, P less than 0.001). These results suggest that deficient osteoblast function could be responsible for osteopenia in diabetics.

References

Sep 1, 1979·The Journal of Clinical Endocrinology and Metabolism·H HeathS B Arnaud
Jan 29, 1976·The New England Journal of Medicine·M E LevinL V Avioli
May 1, 1988·Calcified Tissue International·J AubiaJ Masramon
Oct 1, 1971·Annals of Internal Medicine
Apr 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·J S PerlishR Fleischmajer
Sep 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·S GoldsteinJ S Soeldner
Jul 1, 1984·American Journal of Physical Anthropology·C OberJ Buettner-Janusch
Jan 1, 1981·Calcified Tissue International·R M ShoreG J Bargman

❮ Previous
Next ❯

Citations

Jul 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M InabaH Morii
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y KatayamaN Nagata
Sep 1, 1991·Calcified Tissue International·R Bouillon
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M InabaH Morii
Mar 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·A A RezendeF A Leone
Jul 1, 1996·Journal of Diabetes and Its Complications·M SosaP Betancor
Sep 5, 2001·Diabetes Research and Clinical Practice·G K ReddyC S Enwemeka
Dec 16, 1998·Kidney International·T Weinreich
Mar 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·S J GallacherA C MacCuish
Mar 5, 2005·Clinical Rheumatology·Lahsen AchemlalAbdellah El Maghraoui
Jan 23, 2016·Orthodontics & Craniofacial Research·K AritaN Yoshida
Dec 6, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Christopher A Blount, Casey Leser
Mar 1, 2008·Diabetes & Metabolism·A RäkelJ LeLorier
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M InabaY Nishizawa
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaaki InabaYoshiki Nishizawa
Mar 31, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Toshiyuki NakaoUNKNOWN Japanese Society for Dialysis Therapy
Nov 27, 2002·Archives of Oral Biology·Naoyuki MishimaHidehiro Ozawa
Jun 8, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·P GunczlerJ R Weisinger
Jul 16, 2008·Brazilian Oral Research·Evanice Menezes Marçal VieiraMônica Fernandes Gomes
Feb 1, 1994·Diabetes Research and Clinical Practice·F GregorioP Fumelli
Dec 15, 2006·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·V GopalakrishnanN Srinivasan
Dec 20, 2008·The Journal of International Medical Research·I CapogluZ Umudum
Oct 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Saleh AminHossam Hodeib
Feb 1, 1991·Diabetologia·G Tchobroutsky
Oct 16, 2008·The Journal of Clinical Endocrinology and Metabolism·Jose Manuel Fernández-RealJavier Ibañez
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·Y S ChungL A Fitzpatrick
Sep 27, 2019·Annals of the New York Academy of Sciences·Fawzy Ali Saad
Mar 5, 2015·Endocrine Reviews·Matthew P Gilbert, Richard E Pratley
Nov 5, 1998·Aging : Clinical and Experimental Research·C GennariR Nuti
Oct 24, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Farsad AfshinniaTooraj Zahedi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.