Suggestions for Improving the Characterization of Risk from Exposures to Per and Polyfluorinated Alkyl Substances.

Environmental Toxicology and Chemistry
Antti T MikkonenMark S Johnson

Abstract

Many state and federal environmental and health agencies have developed risk-based criteria for assessing the risk of adverse health effects of per- and polyfluorinated alkyl substances (PFAS) exposure to humans and the environment. However, the criteria that have been developed vary; drinking water criteria developed for perfluorooctanoic acid, for example, can vary by up to 750 fold. This is due to differences and variability in the data and information used, study/endpoint selection, assumptions and magnitude of uncertainty factors used in the absence and extrapolation of critical effect data, differences in underlying approaches to addressing exposure within criteria development, and/or policy decisions on levels of acceptable risk. We have critically evaluated the methods used to develop these criteria while focusing on derivation and application of drinking water criteria and discuss a range of improvements to risk-characterization practice recently presented at a Focused Topic Meeting on PFAS conducted by the Society of Environmental Toxicology and Chemistry in Durham, North Carolina, USA, 12 to 15 August 2019. We propose methods that consider maximizing the use of disparate data streams, seeking patterns, and proposing ...Continue Reading

References

Aug 1, 1980·American Industrial Hygiene Association Journal·F D Griffith, J E Long
Feb 1, 1997·Regulatory Toxicology and Pharmacology : RTP·H J KlimischU Tillmann
Jul 17, 1998·Risk Analysis : an Official Publication of the Society for Risk Analysis·J C SwartoutR E Keenan
Jul 22, 1998·Regulatory Toxicology and Pharmacology : RTP·M N PietersW Slob
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andrew M SeacatJohn L Butenhoff
Sep 7, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·John ButenhoffPeter Thomford
Dec 31, 2002·Toxicology·Andrew M SeacatJohn L Butenhoff
Nov 1, 2003·Environmental Toxicology and Chemistry·Paul D JonesJohn P Giesy
Dec 4, 2003·Environmental Health Perspectives·Geary W OlsenLarry R Zobel
Dec 3, 2004·Drug and Chemical Toxicology·Roger G PerkinsMatthew J Palazzolo
Dec 17, 2004·Journal of Veterinary Pharmacology and Therapeutics·P L Toutain, A Bousquet-Mélou
Apr 1, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·J L C M Dorne, A G Renwick
Jul 21, 2005·Nutrition Reviews·Michael N SawkaRobert Carter
Jan 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauMark J Strynar
Jul 20, 2006·Annual Review of Nutrition·Kevin Fritsche
Jul 7, 2007·Critical Reviews in Toxicology·Bas G H Bokkers, Wout Slob
Mar 25, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Margie M Peden-AdamsDeborah E Keil
Jul 28, 2009·Toxicology·Scott E LovelessRobert C Buck
Sep 8, 2009·Environmental Science & Technology·Robin Vestergren, Ian T Cousins
Jun 1, 2010·Neurotoxicity Research·Natalia OnishchenkoSandra Ceccatelli
Jun 4, 2010·International Journal of Toxicology·Jozef J W M MertensCraig H Farr
Jun 22, 2010·Regulatory Toxicology and Pharmacology : RTP·Ryuichi HasegawaAkihiko Hirose
Nov 3, 2010·Toxicology and Applied Pharmacology·J Allen DavisQ Jay Zhao
Apr 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Madisa B MaconSuzanne E Fenton
Apr 27, 2011·Environmental Science & Technology·Matthew Lorber, Peter P Egeghy
Jan 1, 2010·PPAR Research·Christopher LauMichael L Cunningham
Feb 2, 2012·The Journal of Toxicological Sciences·Mutsuko Hirata-KoizumiAkihiko Hirose
Apr 21, 2012·American Journal of Epidemiology·Kristina W WhitworthMatthew P Longnecker
Jul 3, 2013·Environmental Health : a Global Access Science Source·Olwenn V MartinAndreas Kortenkamp
Jul 31, 2013·Environment International·Francisca PérezMarinella Farré
Jan 15, 2014·The Journal of Toxicological Sciences·Mika TakahashiAkihiko Hirose
Apr 23, 2014·Environmental Toxicology·Hina KatoAkihiko Hirose
Apr 24, 2014·Environmental Health Perspectives·Andrew A RooneyKristina A Thayer

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