PMID: 2487151Nov 1, 1989Paper

Suggestive evidence that genes controlling invasion and metastasis of T-cell lymphomas are located on mouse chromosome 3

Genes, Chromosomes & Cancer
L VerschaeveP De Baetselier

Abstract

Cell lines differing in their malignant potential have been derived from the murine BW5147 T-cell lymphosarcoma. To evaluate the involvement of chromosomal aberrations in tumor progression within this model, we have analyzed the karyotypes and the in vitro invasiveness of 13 related nonmetastatic and metastatic variants. Giemsa banding revealed the presence of several marker chromosomes, one of which was of particular importance. Depending on the cell line, four variants of this marker I were found: Marker Ia corresponds to two translocated chromosomes 3, marker Ib is a deleted Ia marker, marker Ic is a Ib translocated to small unidentified chromosome fragment, and marker Id is a further deleted Ib marker. The Ia and Id markers were characteristic for the noninvasive, nonmetastatic lines, whereas the Ib and Ic markers predominated in the invasive, metastatic variants. The results suggest that metastasis-enhancing genes are located between the D and FI band of mouse chromosome 3 and that metastasis-suppressing genes are located between the FI and H band of the same chromosome.

References

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Citations

Nov 5, 1997·International Journal of Cancer. Journal International Du Cancer·J KlominekD Hauzenberger
Nov 1, 1991·Journal of Cellular Physiology·S B MilamR J Klebe
Jan 1, 1993·Journal of Surgical Oncology. Supplement·G BazzoniE Dejana
Mar 1, 1994·Medicinal Research Reviews·D CoxK Yoshida
Apr 1, 1991·Scandinavian Journal of Immunology·I VirtanenE Saksela
Jul 1, 1994·Cell Adhesion and Communication·R G ChiriviR Giavazzi
Dec 1, 1994·Leukemia & Lymphoma·G De RossiC E Grossi
Jun 17, 1998·Cancer Investigation·R J SandersF G Giancotti
Dec 1, 1990·Journal of Dental Research·M HormiaI Virtanen
Jul 1, 1992·Journal of Periodontology·B SteffensenR J Klebe
Oct 1, 2016·Molecular Biology of the Cell·Charles H Streuli

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