Suggestive linkage between markers on chromosome 19q13.2 and nonsyndromic orofacial cleft malformation

Genomics
M MartinelliM Tognon

Abstract

Nonsyndromic cleft lip with or without cleft palate (OFC) is a common birth defect that has genetic bases. The nature of the genetic contribution is still to be clarified; however, some chromosome regions and candidate genes have been proposed for this malformation. We examined linkage between BCL3, a proto-oncogene located in 19q13.2, and OFC in a sample composed of 40 multiplex pedigrees using both nonparametric and parametric methods. The affected pedigree member statistics and the transmission disequilibrium test supported a role for BCL3 in causing OFC, while no evidence of linkage or genetic heterogeneity was found with the lod score method.

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Related Concepts

BCL3 protein, human
Chromosomes, Human, Pair 19
Cleft Lip
Cleft Palate, Isolated
Genetic Markers
Genetic Linkage Analysis
Genealogical Tree
Proto-Oncogene Proteins
Proto-Oncogenes
Transcription Factor

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