Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Philipp A LangFlorian Lang

Abstract

Hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia with fragmented erythrocytes, thrombocytopenia, and acute renal failure. Lack of complement inactivating factor H predisposes to the development of atypical HUS. Little is known about mechanisms linking complement activation with loss of erythrocyte integrity during HUS. Recent studies disclosed that increased cytosolic Ca2+ activity and cellular ceramide trigger programmed erythrocyte death or eryptosis, characterized by cell shrinkage and phosphatidylserine exposure at the erythrocyte surface. In the present study, we investigated whether eryptosis occurs during the course of HUS. To this end, erythrocytes from healthy volunteers were exposed to plasma from a patient with severe idiopathic recurrent HUS secondary to factor H depletion. Phosphatidylserine exposure (Annexin binding), cell volume (forward scatter), cytosolic Ca2+ activity (Fluo3 fluorescence), and ceramide formation [anti-ceramide antibody and enzymatic (diacylgycerol kinase) analysis] were determined. Exposure of erythrocytes to plasma from the patient, but not to plasma from healthy individuals, triggered Annexin binding. The effect of plasma on erythrocyte Annexin binding was abolished by pl...Continue Reading

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Citations

May 2, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Friedrich C Luft
Dec 21, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Daniela S KempeFlorian Lang
Jul 19, 2008·Archives of Toxicology·Hasan MahmudFlorian Lang
Mar 22, 2013·Archives of Toxicology·Kashif Jilani, Florian Lang
Oct 5, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Olivier M NiemoellerFlorian Lang
Dec 21, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Ravi S KasinathanFlorian Lang
Nov 11, 2010·The Journal of Membrane Biology·Yuliya V Kucherenko, Florian Lang
Feb 3, 2009·Annals of Hematology·Sergios GatidisFlorian Lang
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Olivier M NiemoellerFlorian Lang
Sep 28, 2007·Pflügers Archiv : European journal of physiology·Michael FöllerFlorian Lang
Dec 7, 2007·Pflügers Archiv : European journal of physiology·Jan P NicolayFlorian Lang
Jun 29, 2011·Journal of Agricultural and Food Chemistry·Sergios GatidisFlorian Lang
Dec 3, 2011·Journal of Agricultural and Food Chemistry·Mohanad ZbidahFlorian Lang
Sep 20, 2011·Journal of Natural Products·Kashif JilaniFlorian Lang
Apr 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michael FöllerRobert Feil
Aug 17, 2006·Antioxidants & Redox Signaling·Florian LangThomas Wieder
Jan 24, 2013·Cardiovascular Research·Hasan MahmudRudolf A de Boer
Feb 21, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Peter J BentzenFlorian Lang
Sep 1, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Philipp AttanasioFlorian Lang
Jan 23, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Olivier M NiemoellerFlorian Lang
Mar 6, 2008·Kidney & Blood Pressure Research·Michael FöllerFlorian Lang
May 6, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Saisudha KokaFlorian Lang
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shefalee K BhavsarFlorian Lang
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Syed M QadriFlorian Lang
May 24, 2011·Malaria Journal·Adil BallalFlorian Lang
May 16, 2009·Malaria Journal·Diwakar BobbalaFlorian Lang
Feb 26, 2013·PloS One·Majed AbedFlorian Lang
Jul 19, 2013·Toxins·Kashif JilaniFlorian Lang
Sep 13, 2013·Toxins·Adrian LupescuFlorian Lang
Oct 25, 2013·Toxins·Elisabeth LangFlorian Lang
Mar 22, 2014·Toxins·Leonie FrauenfeldFlorian Lang
Dec 24, 2013·Antioxidants & Redox Signaling·Florian LangMichael Föller
Apr 20, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Majed AbedFlorian Lang
Jun 14, 2014·International Journal of Hematology·Rosi BissingerFlorian Lang
Dec 3, 2014·Toxicology and Applied Pharmacology·Itzel-Citlalli Aguilar-DoradoJosé-Víctor Calderón-Salinas
Jul 6, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Michael TheurerFlorian Lang
Nov 15, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Adrian LupescuFlorian Lang
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Jan 19, 2016·Pesticide Biochemistry and Physiology·Arbace OfficiosoFlorian Lang
Oct 17, 2012·Toxicology·Majed AbedFlorian Lang
Jun 26, 2012·Toxicology·Adrian LupescuFlorian Lang

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