Suicidal ideation in patients with systemic lupus erythematosus: incidence and risk factors

Rheumatology
Chi Chiu MokPaul Siu Fai Yip

Abstract

To study the incidence of suicidal ideation in patients with SLE and the associated risk factors. Consecutive patients who fulfilled four or more ACR criteria for SLE were recruited. Suicidal thought in the preceding month was assessed by three direct questions. The intensity of suicidal ideation was assessed by the validated Beck Scale for Suicidal Ideation (BSSI). Socio-demographic data, clinical manifestations, Hospital Anxiety and Depression Scale (HADS), SLEDAI and SLICC/ACR Damage Index (SDI) scores were compared between patients with and without suicidal thoughts. Linear regression was used to study the factors associated with higher BSSI scores. Of the 367 SLE patients studied (96% women; mean age 40.2 years (S.D. 13), mean disease duration 9.3 years (S.D. 7.2), 67 (18.3%) patients had clinically active SLE and 137 (37.3%) had organ damage (SDI ≥ 1). Suicidal thoughts were present in 44 (12%) patients. Patients with suicidal thoughts, compared with those without, had significantly higher mean SLEDAI scores in the preceding year [5.1 (S.D. 4.0) vs 2.9 (S.D. 2.7), P < 0.001], higher SDI [1.4 (S.D. 1.7) vs 0.6 (S.D. 1.1), P < 0.001], HADS-depression [11.2 (S.D. 4.7) vs 4.4 (S.D. 3.8), P < 0.001] and anxiety [12.2 (S.D. 4.9...Continue Reading

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Citations

Aug 1, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Philippe CourtetDeborah Ducasse
Jan 11, 2016·The British Journal of Dermatology·I JalenquesUNKNOWN Lupus Group
Mar 7, 2017·International Journal of Rheumatic Diseases·Geraldine Zamora-RacazaMichael H Weisman
Dec 22, 2017·Rheumatology International·Elena P CalandreMahmoud Slim
Dec 23, 2017·Inflammatory Bowel Diseases·Renée M Marchioni BeeryJoshua R Korzenik
Jul 24, 2018·Journal of Clinical Gastroenterology·Jana G HashashEva Szigethy
Feb 9, 2020·Journal of Health Psychology·Valentina MihajlovicJill A Jacobson
Apr 4, 2021·Journal of Clinical Medicine·Irini GergianakiGeorge Bertsias

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