Suicide attempts and the tryptophan hydroxylase gene

Molecular Psychiatry
M AbbarCatherine Buresi

Abstract

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme of serotonin synthesis. In this case-control study, we investigated whether the TPH gene was a susceptibility factor for suicidal behavior. Seven polymorphisms spanning the entire gene were studied in a case-control study including 231 individuals who had attempted suicide and 281 controls. Significant associations were found between variants in introns 7, 8 and 9 (chi(2) = 11.2, df = 1, P< 0.0008 for the allele distribution; these loci are in complete linkage disequilibrium) and in the 3' noncoding region (chi(2) = 30.94, P = 0.0014) and suicide attempt. The association was strongest for subjects who had attempted suicide by violent means and who had a history of major depression. No significant association was observed between suicide attempts and polymorphisms in the promoter, intron 1 and intron 3. The results presented here, and those of previous studies, suggest that a genetic variant of the 3' part of the TPH gene may be a susceptibility factor for a phenotype combining suicidal behavior, mood disorder and impulsive aggression.

References

Jun 1, 1981·Archives of General Psychiatry·L TräskmanL Sjöstrand
Oct 1, 1995·Archives of General Psychiatry·M AbbarA Malafosse
Sep 1, 1994·The Journal of School Health·S H Terwilliger
Dec 1, 1996·Archives of General Psychiatry·D A BrentJ Connolly
Nov 5, 1997·The Psychiatric Clinics of North America·A RoyM Sarchiapone
Jan 14, 1998·Nature Medicine·J J Mann
Jan 22, 1998·Archives of General Psychiatry·F BellivierA Malafosse
Jul 22, 1998·Archives of General Psychiatry·D A NielsenM Linnoila

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Citations

May 24, 2007·Molecular Neurobiology·Kazuhiro Nakamura, Hiroyuki Hasegawa
Jan 7, 2004·Biological Psychiatry·Philippe CourtetAlain Malafosse
Aug 14, 2003·Biological Psychiatry·Dan RujescuHans Jürgen Möller
Jul 10, 2003·Journal of Psychiatric Research·Victoria ArangoJ John Mann
Feb 8, 2006·Molecular Psychiatry·B BondyP Zill
Feb 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ghazal ZaboliRosario Leopardi
Dec 5, 2003·Genes, Brain, and Behavior·A R Hariri, D R Weinberger
Mar 5, 2004·The Tohoku Journal of Experimental Medicine·Maki OhtaniNaofumi Yoshioka
Apr 29, 2008·The Psychiatric Clinics of North America·Jelena BrezoGustavo Turecki
Mar 13, 2003·Mayo Clinic Proceedings·Stephen M AnsellAyalew Tefferi
May 29, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Scott T WilsonJ John Mann
Jul 20, 2006·Genes, Brain, and Behavior·L Keltikangas-JärvinenTerho Lehtimäki
Jan 13, 2006·Brain Research·Martin ReuterJürgen Hennig
May 17, 2005·Medical Hypotheses·Katherine A RaymerCatherine R Price
Apr 6, 2005·Psychiatry Research·Jasminka StefuljBranimir Jernej
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Dominik KiserJudith R Homberg
Jun 8, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Niki AntypaDan Rujescu
Jul 10, 2014·BMC Psychiatry·Thelma Beatriz González-CastroCarlos Alfonso Tovilla-Zárate
Dec 1, 2006·Journal of Affective Disorders·Markus JokelaLiisa Keltikangas-Järvinen
Sep 15, 2010·Journal of Psychopharmacology·Xenia GondaZoltan Rihmer
Dec 19, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Frank BellivierAlain Malafosse
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Philippe CourtetAlain Malafosse
Jan 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Fabrice JollantPhilippe Courtet
Aug 12, 2005·Psychiatric Genetics·Philippe CourtetAlain Malafosse
Oct 26, 2002·Molecular Psychiatry·D RujescuH-J Möller
Feb 26, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rhonda P Patrick, Bruce N Ames
Jan 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M Reuter, J Hennig
Mar 30, 2011·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Shelley H Carson
Nov 23, 2012·Biological Research for Nursing·Sang-Eun JunMargaret M Heitkemper
Jul 13, 2002·American Journal of Medical Genetics·A Lalovic, G Turecki
Jan 13, 2005·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Philippe CourtetAlain Malafosse
Feb 18, 2004·Harvard Review of Psychiatry·Ross J Baldessarini, John Hennen

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