Suicide, depression, and isotretinoin: is there a causal link?

Journal of the American Academy of Dermatology
D G JacobsM Brewer

Abstract

This paper examines the existing literature and MedWatch reports concerning a proposed relationship between isotretinoin and depression and suicide. The authors provide a brief overview of the biology of isotretinoin and depressive disorder and find no basis for a putative molecular mechanism linking the two. They also address the complexities of Substance-Induced Mood Disorder (SIMD) as a psychiatric diagnosis and its relevance to isotretinoin. Based on this review, the authors conclude that there is no evidence to support a causal connection between isotretinoin and major depression or suicide, because reported cases do not meet the established criteria for causality. The authors also conclude, however, that it is important for dermatologists to be aware of the risk factors for suicide and to monitor patients who exhibit depressive symptoms.

Citations

Apr 9, 2005·The New England Journal of Medicine·William D James
Nov 14, 2006·Journal of Paediatrics and Child Health·Diana PurvisPeter Watson
Aug 31, 2002·BMJ : British Medical Journal·Guy F Webster
Aug 8, 2006·Postgraduate Medical Journal·J Ayer, N Burrows
Sep 10, 2011·The Journal of Clinical Psychiatry·J Douglas BremnerPeter J McCaffery
Feb 20, 2007·Psychological Reports·Yeşim KaymakEnder Taner
Oct 22, 2011·Clinics in Dermatology·Elie B Lowenstein, Eve J Lowenstein
Jan 20, 2010·Clinics in Dermatology·Dimitris RigopoulosAndreas D Katsambas
Sep 29, 2009·Journal of Affective Disorders·Linda C SchafferAmber Miller
Aug 5, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Simon TrentSarah J Bailey
Sep 13, 2008·Seminars in Cutaneous Medicine and Surgery·Megan Brelsford, Trisha Clarke Beute
Oct 16, 2007·Neurotoxicology and Teratology·Sherry A FergusonKimberly J Berry
Aug 21, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Douglas Bremner, Peter McCaffery
Apr 29, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·M La Placa
May 30, 2003·The Journal of Dermatology·Kabir Sardana, Virendra N Sehgal
May 20, 2003·The Australasian Journal of Dermatology·Alan J Cooper, UNKNOWN Australian Roaccutane Advisory Board
Apr 29, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·O AricanO Ozbulut
Jan 29, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·L M H RehnM Henriksson
Jul 26, 2006·International Journal of Dermatology·Jamison E Strahan, Sharon Raimer
Mar 22, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·José Antonio, Suárez Tallé
Jan 18, 2006·International Journal of Clinical Practice·A M Layton
Dec 9, 2010·The British Journal of Dermatology·E J McGrathS M Skevington
Jan 26, 2013·International Journal of Dermatology·Zuzana Nevoralová, Dagmar Dvořáková
Oct 9, 2013·Dermatologic Therapy·Shelbi C Jim On, Joshua Zeichner
Jan 22, 2011·The British Journal of Dermatology·M J D GoodfieldA D Ormerod
Jan 13, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tal FriedmanYoram Barak
Aug 23, 2005·Dermatologic Clinics·Peter R Hull, Carl D'Arcy
Apr 22, 2015·American Journal of Clinical Dermatology·Mollie D OudenhovenDean S Morrell
May 4, 2010·Dermato-endocrinology·Alison Layton
Jul 1, 2010·Medical Journal, Armed Forces India·A Kumar, V K Kumar
Jul 15, 2016·Expert Review of Clinical Pharmacology·Lindsey B BauerAli Alikhan
Jul 2, 2003·Journal of the American Academy of Dermatology·Harald GollnickUNKNOWN Global Alliance to Improve Outcomes in Acne
Jul 5, 2003·The Annals of Pharmacotherapy·Shelly J Enders, Jason M Enders
Apr 2, 2005·Clinics in Dermatology·Edith OrionRonni Wolf
Jun 19, 2004·The Journal of Dermatological Treatment·Ayten FerahbasCanan Gul Kilic
Jun 8, 2002·Pharmacoepidemiology and Drug Safety
Dec 6, 2018·Dermatologic Therapy·Safak MetekogluMehmet Akalin
May 12, 2006·Journal of Neurobiology·N E Rawson, A-S LaMantia
May 9, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Susanne Astner, Sandy S Tsao
Jul 22, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherry A FergusonKimberly J Berry
Jan 6, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kally C O'ReillySarah J Bailey
Jul 13, 2002·American Journal of Clinical Dermatology·Yebabe M Mengesha, Michelle L Bennett
Jun 20, 2003·American Journal of Clinical Dermatology·Peter R Hull, Carl D'Arcy
Sep 29, 2006·Southern Medical Journal·Jeffery P Greene
Aug 25, 2009·The Journal of Dermatological Treatment·Kübra Eren BozdağBirmay Cam
Mar 31, 2006·Pediatric Annals·Jonette E Keri
Dec 17, 2004·International Clinical Psychopharmacology·Yoram BarakHaim Y Knobler
May 7, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·T ErgunS Zaimoglu
Jul 1, 2010·Expert Review of Clinical Pharmacology·Laura J Savage, Alison M Layton
Jan 12, 2017·The Medical Journal of Australia·Alan J Cooper, Victoria Rebecca Harris

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