Suicide due to oral ingestion of lidocaine: a case report and review of the literature

Forensic Science International : Synergy
F CentiniV Fineschi

Abstract

The Authors describe a rare case of suicide in a 31-year-old woman, due to oral ingestion of lidocaine; the histological and toxicological findings are discussed to provide useful information to the present experience with this particular modality of death. Histological examination revealed generalized stasis. In the myocardium we observed segmentation of the myocardial cells and/or widening of intercalated discs and associated group of hypercontracted myocardial cells with "square" nuclei in line with hyperdistended ones. Non-eosinophilic bands of hypercontracted sarcomeres alternating with stretched, often apparently separated sarcomeres, small foci of paradiscal contraction band necrosis, and perivascular fibrosis were observed too. Lidocaine was detected in the subject's urine through immunoenzymatic screening. Toxicological analysis by solid-liquid extraction and gas chromatography-mass spectrometry (GC-MS) analysis, was carried out to identify and quantify the individual substances present in the biological fluids and organs. Lidocaine concentrations were as follows: blood 31 microg/mL, gastric content 2.5 g, liver 10 microg/g, kidney 12 microg/g, brain 9 microg/g, spleen 24 microg/g, lung 84 microg/g, heart 9 microg/g, u...Continue Reading

References

May 1, 1978·Clinical Pharmacokinetics·N L Benowitz, W Meister
Jun 1, 1992·The American Journal of Forensic Medicine and Pathology·G R Nichols, G J Davis
Jan 1, 1990·Journal of Toxicology. Clinical Toxicology·A P JonvilleM Breteau
Jan 16, 1986·The New England Journal of Medicine·Y AmitaiF H Lovejoy
Mar 1, 1980·American Journal of Diseases of Children·R I Sakai, J E Lattin
Aug 1, 1996·Therapeutic Drug Monitoring·M L ShiffmanE B Thompson
May 9, 2003·Archives of Pharmacal Research·Sang-Ki LeeHee-Sun Chung
Sep 18, 2004·BMJ : British Medical Journal·Olaf DrummerUNKNOWN International Toxicology Advisory Group
Aug 4, 2005·International Journal of Legal Medicine·Vittorio FineschiEmanuela Turillazzi
Nov 1, 2005·International Journal of Cardiology·Vittorio FineschiEmanuela Turillazzi

❮ Previous
Next ❯

Citations

Dec 4, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mohcine DoumiriWajdi Maazouzi
Jun 10, 2011·Clinical Pharmacokinetics·Marcel P H van den BroekCatharine M A Rademaker
Oct 18, 2015·Thérapie·Joachim AlexandreSophie Fedrizzi
Mar 8, 2008·Expert Opinion on Drug Safety·Vilma A SardãoPaulo J Oliveira
Jul 10, 2010·Toxicology Mechanisms and Methods·R J Dinis-OliveiraT Magalhães
Mar 17, 2015·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Viktor MartosAlessandro Ceschi
Jan 17, 2016·Forensic Science International : Synergy·F BévalotL Fanton
Sep 4, 2015·Forensic Science International : Synergy·Francesco Paolo BusardòGuido Romano
Mar 10, 2015·Forensic Science International : Synergy·Evelyn PawlikThomas Daldrup
May 27, 2016·Journal of Medical Case Reports·Carlson B SamaFru F Angwafo
Oct 5, 2016·Hospital Pharmacy·Daniel L MoellentinJames Barbour
Jun 18, 2019·Drug Testing and Analysis·Raimo A Ketola, Pirkko Kriikku
Jul 7, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Robin E Ferner, Jeffrey K Aronson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Dermatitis : Contact, Atopic, Occupational, Drug
Antoine AmadoJames S Taylor
The Journal of Allergy and Clinical Immunology
Lennart VenemalmWilliam Smith
The Journal of Emergency Medicine
Yael Shachor-MeyouhasItai Shavit
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Maren StahlMarkus Zutt
© 2021 Meta ULC. All rights reserved