Suitability of the ruffe (Gymnocephalus cernua [L.]) for investigations on activity of hepatic enzymes induced by xenobiotics

Ecotoxicology and Environmental Safety
S Weber, L Karbe

Abstract

Activity measurements of enzymes catalyzing (i) the oxidation of xenobiotics (phase I) and (ii) the conjugation of metabolites produced in phase I (phase II) were carried out in ruffe to test its suitability for biological monitoring. Ruffe typically lives in the lower regions of rivers and in estuaries where monitoring is of particular interest for estimating the amount of pollutants introduced into the sea. The flounder, already examined for this purpose, is used as reference organism. In ruffe, the enzymatic activity (7-ethoxycoumarin-O-deethylase (ECOD) and 7-ethoxyresorufin-O-deethylase (EROD)) increased with the contamination of the river toward Hamburg whereas in flounder it did not. The absence of a correlation between induction of the enzymatic activity in flounder and environmental contamination is attributed to the higher readiness of the flounder to migrate. Therefore, mixed function oxygenase activity found in flounders may not represent the inducing capacity of the local concentrations of xenobiotics. Since ECOD activity in ruffe was 5 to 20 times higher compared to the flounder, histopathological findings of investigations of the liver tissue were considered. Destruction or pathological changes of the endoplasmat...Continue Reading

Citations

Aug 24, 2000·Critical Reviews in Toxicology·J J WhyteD E Tillitt
Apr 28, 2010·Biodegradation·Archana Chauhan, Rakesh K Jain
Feb 1, 2003·Environmental Toxicology and Pharmacology·Ron van der OostNico P E Vermeulen

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